Prognostic significance of disease-free interval in head and neck cutaneous squamous cell carcinoma with nodal metastases

Ardalan Ebrahimi; Jonathan R. Clark; Nazanin Ahmadi; Carsten E. Palme; Gary J. Morgan; Michael J. Veness

doi:10.1002/hed.23096

Prognostic significance of disease-free interval in head and neck cutaneous squamous cell carcinoma with nodal metastases

Ardalan Ebrahimi^*, Jonathan R. Clark, Nazanin Ahmadi, Carsten E. Palme, Gary J. Morgan, Michael J. Veness

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Background The purpose of this study was to determine whether the disease-free interval (DFI) between treatment of primary head and neck cutaneous squamous cell carcinoma (SCC) and the development of regional metastases is an independent prognostic factor. Methods A retrospective analysis of 229 patients with metastatic nodal head and neck cutaneous SCC, treated with curative intent by surgery ± adjuvant radiotherapy was conducted. Results After adjusting for the effect of nodal staging, extracapsular spread, involved margins, adjuvant radiotherapy, and immunosuppression, a short DFI (≤9 months vs >9 months) was a significant predictor of disease-related mortality (hazard ratio [HR], 3.0; 95% confidence interval [CI], 1.4-6.5; p =.004) and locoregional relapse (HR, 2.0; 95% CI, 1.1-4.0; p =.044). Conclusion The DFI is a potentially powerful independent prognostic factor in patients with regional metastases secondary to head and neck cutaneous SCC. It provides information before definitive treatment that may ultimately assist clinicians in applying a risk-adapted management paradigm.

Original language	English
Pages (from-to)	1138-1143
Number of pages	6
Journal	Head and Neck
Volume	35
Issue number	8
DOIs	https://doi.org/10.1002/hed.23096
Publication status	Published - Aug 2013
Externally published	Yes

Keywords

cutaneous squamous cell carcinoma
disease-free interval
head and neck neoplasms
lymph node metastases
survival

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title = "Prognostic significance of disease-free interval in head and neck cutaneous squamous cell carcinoma with nodal metastases",

abstract = "Background The purpose of this study was to determine whether the disease-free interval (DFI) between treatment of primary head and neck cutaneous squamous cell carcinoma (SCC) and the development of regional metastases is an independent prognostic factor. Methods A retrospective analysis of 229 patients with metastatic nodal head and neck cutaneous SCC, treated with curative intent by surgery ± adjuvant radiotherapy was conducted. Results After adjusting for the effect of nodal staging, extracapsular spread, involved margins, adjuvant radiotherapy, and immunosuppression, a short DFI (≤9 months vs >9 months) was a significant predictor of disease-related mortality (hazard ratio [HR], 3.0; 95% confidence interval [CI], 1.4-6.5; p =.004) and locoregional relapse (HR, 2.0; 95% CI, 1.1-4.0; p =.044). Conclusion The DFI is a potentially powerful independent prognostic factor in patients with regional metastases secondary to head and neck cutaneous SCC. It provides information before definitive treatment that may ultimately assist clinicians in applying a risk-adapted management paradigm.",

keywords = "cutaneous squamous cell carcinoma, disease-free interval, head and neck neoplasms, lymph node metastases, survival",

author = "Ardalan Ebrahimi and Clark, {Jonathan R.} and Nazanin Ahmadi and Palme, {Carsten E.} and Morgan, {Gary J.} and Veness, {Michael J.}",

year = "2013",

month = aug,

doi = "10.1002/hed.23096",

language = "English",

volume = "35",

pages = "1138--1143",

journal = "Head and Neck",

issn = "1043-3074",

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T1 - Prognostic significance of disease-free interval in head and neck cutaneous squamous cell carcinoma with nodal metastases

AU - Ebrahimi, Ardalan

AU - Clark, Jonathan R.

AU - Ahmadi, Nazanin

AU - Palme, Carsten E.

AU - Morgan, Gary J.

AU - Veness, Michael J.

PY - 2013/8

Y1 - 2013/8

N2 - Background The purpose of this study was to determine whether the disease-free interval (DFI) between treatment of primary head and neck cutaneous squamous cell carcinoma (SCC) and the development of regional metastases is an independent prognostic factor. Methods A retrospective analysis of 229 patients with metastatic nodal head and neck cutaneous SCC, treated with curative intent by surgery ± adjuvant radiotherapy was conducted. Results After adjusting for the effect of nodal staging, extracapsular spread, involved margins, adjuvant radiotherapy, and immunosuppression, a short DFI (≤9 months vs >9 months) was a significant predictor of disease-related mortality (hazard ratio [HR], 3.0; 95% confidence interval [CI], 1.4-6.5; p =.004) and locoregional relapse (HR, 2.0; 95% CI, 1.1-4.0; p =.044). Conclusion The DFI is a potentially powerful independent prognostic factor in patients with regional metastases secondary to head and neck cutaneous SCC. It provides information before definitive treatment that may ultimately assist clinicians in applying a risk-adapted management paradigm.

AB - Background The purpose of this study was to determine whether the disease-free interval (DFI) between treatment of primary head and neck cutaneous squamous cell carcinoma (SCC) and the development of regional metastases is an independent prognostic factor. Methods A retrospective analysis of 229 patients with metastatic nodal head and neck cutaneous SCC, treated with curative intent by surgery ± adjuvant radiotherapy was conducted. Results After adjusting for the effect of nodal staging, extracapsular spread, involved margins, adjuvant radiotherapy, and immunosuppression, a short DFI (≤9 months vs >9 months) was a significant predictor of disease-related mortality (hazard ratio [HR], 3.0; 95% confidence interval [CI], 1.4-6.5; p =.004) and locoregional relapse (HR, 2.0; 95% CI, 1.1-4.0; p =.044). Conclusion The DFI is a potentially powerful independent prognostic factor in patients with regional metastases secondary to head and neck cutaneous SCC. It provides information before definitive treatment that may ultimately assist clinicians in applying a risk-adapted management paradigm.

KW - cutaneous squamous cell carcinoma

KW - disease-free interval

KW - head and neck neoplasms

KW - lymph node metastases

KW - survival

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DO - 10.1002/hed.23096

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EP - 1143

JO - Head and Neck

JF - Head and Neck

IS - 8

ER -

Prognostic significance of disease-free interval in head and neck cutaneous squamous cell carcinoma with nodal metastases

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Keywords

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