Prognostic significance of lymph node density in squamous cell carcinoma of the tongue

Wilson Ong, Runfeng Zhao, Benjamin Lui, Winson Tan, Ardalan Ebrahimi, Jonathan R. Clark, Khee Chee Soo, Ngian Chye Tan, Hiang Khoon Tan, N. Gopalakrishna Iyer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Background The prognostic significance of lymph node density in oral squamous cell carcinoma (OSCC) has been well recognized. However, its use in a specific subsite of the tongue has not been evaluated. The purpose of this study was to determine the prognostic significance of lymph node density in tongue squamous cell carcinoma (SCC). Methods A retrospective analysis of 99 patients with tongue SCC who underwent primary curative resection and neck dissection was conducted. Overall survival (OS) and disease-specific survival (DSS) was used to evaluate the prognostic significance of lymph node density. Results Lymph node density (using a cutoff of 0.06) was shown to be an independent predictor of OS and DSS. The impact of lymph node density on OS and DSS remained significant on multivariate analysis, whereas conventional nodal staging was not. An alternative staging strategy incorporating depth of invasion and lymph node density performs better than conventional TNM staging in predicting survival. Conclusion Our data suggest that lymph node density is a reliable and applicable predictor of prognosis in patients with tongue SCC.

Original languageEnglish
Pages (from-to)E859-E866
Number of pages8
JournalHead and Neck
Volume38 Suppl 1
DOIs
Publication statusPublished - 1 Apr 2016
Externally publishedYes

Keywords

  • depth of invasion
  • head and neck cancer
  • lymph node ratio
  • oral squamous cell carcinoma (OSCC)
  • staging
  • tongue cancer

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