Prognostic significance of lymph node density in squamous cell carcinoma of the tongue

Wilson Ong; Runfeng Zhao; Benjamin Lui; Winson Tan; Ardalan Ebrahimi; Jonathan R. Clark; Khee Chee Soo; Ngian Chye Tan; Hiang Khoon Tan; N. Gopalakrishna Iyer

doi:10.1002/hed.24113

Prognostic significance of lymph node density in squamous cell carcinoma of the tongue

Wilson Ong, Runfeng Zhao, Benjamin Lui, Winson Tan, Ardalan Ebrahimi, Jonathan R. Clark, Khee Chee Soo, Ngian Chye Tan, Hiang Khoon Tan, N. Gopalakrishna Iyer^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

Background The prognostic significance of lymph node density in oral squamous cell carcinoma (OSCC) has been well recognized. However, its use in a specific subsite of the tongue has not been evaluated. The purpose of this study was to determine the prognostic significance of lymph node density in tongue squamous cell carcinoma (SCC). Methods A retrospective analysis of 99 patients with tongue SCC who underwent primary curative resection and neck dissection was conducted. Overall survival (OS) and disease-specific survival (DSS) was used to evaluate the prognostic significance of lymph node density. Results Lymph node density (using a cutoff of 0.06) was shown to be an independent predictor of OS and DSS. The impact of lymph node density on OS and DSS remained significant on multivariate analysis, whereas conventional nodal staging was not. An alternative staging strategy incorporating depth of invasion and lymph node density performs better than conventional TNM staging in predicting survival. Conclusion Our data suggest that lymph node density is a reliable and applicable predictor of prognosis in patients with tongue SCC.

Original language	English
Pages (from-to)	E859-E866
Number of pages	8
Journal	Head and Neck
Volume	38 Suppl 1
DOIs	https://doi.org/10.1002/hed.24113
Publication status	Published - 1 Apr 2016
Externally published	Yes

Keywords

depth of invasion
head and neck cancer
lymph node ratio
oral squamous cell carcinoma (OSCC)
staging
tongue cancer

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title = "Prognostic significance of lymph node density in squamous cell carcinoma of the tongue",

abstract = "Background The prognostic significance of lymph node density in oral squamous cell carcinoma (OSCC) has been well recognized. However, its use in a specific subsite of the tongue has not been evaluated. The purpose of this study was to determine the prognostic significance of lymph node density in tongue squamous cell carcinoma (SCC). Methods A retrospective analysis of 99 patients with tongue SCC who underwent primary curative resection and neck dissection was conducted. Overall survival (OS) and disease-specific survival (DSS) was used to evaluate the prognostic significance of lymph node density. Results Lymph node density (using a cutoff of 0.06) was shown to be an independent predictor of OS and DSS. The impact of lymph node density on OS and DSS remained significant on multivariate analysis, whereas conventional nodal staging was not. An alternative staging strategy incorporating depth of invasion and lymph node density performs better than conventional TNM staging in predicting survival. Conclusion Our data suggest that lymph node density is a reliable and applicable predictor of prognosis in patients with tongue SCC.",

keywords = "depth of invasion, head and neck cancer, lymph node ratio, oral squamous cell carcinoma (OSCC), staging, tongue cancer",

author = "Wilson Ong and Runfeng Zhao and Benjamin Lui and Winson Tan and Ardalan Ebrahimi and Clark, {Jonathan R.} and Soo, {Khee Chee} and Tan, {Ngian Chye} and Tan, {Hiang Khoon} and Iyer, {N. Gopalakrishna}",

year = "2016",

month = apr,

day = "1",

doi = "10.1002/hed.24113",

language = "English",

volume = "38 Suppl 1",

pages = "E859--E866",

journal = "Head and Neck",

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T1 - Prognostic significance of lymph node density in squamous cell carcinoma of the tongue

AU - Ong, Wilson

AU - Zhao, Runfeng

AU - Lui, Benjamin

AU - Tan, Winson

AU - Ebrahimi, Ardalan

AU - Clark, Jonathan R.

AU - Soo, Khee Chee

AU - Tan, Ngian Chye

AU - Tan, Hiang Khoon

AU - Iyer, N. Gopalakrishna

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Background The prognostic significance of lymph node density in oral squamous cell carcinoma (OSCC) has been well recognized. However, its use in a specific subsite of the tongue has not been evaluated. The purpose of this study was to determine the prognostic significance of lymph node density in tongue squamous cell carcinoma (SCC). Methods A retrospective analysis of 99 patients with tongue SCC who underwent primary curative resection and neck dissection was conducted. Overall survival (OS) and disease-specific survival (DSS) was used to evaluate the prognostic significance of lymph node density. Results Lymph node density (using a cutoff of 0.06) was shown to be an independent predictor of OS and DSS. The impact of lymph node density on OS and DSS remained significant on multivariate analysis, whereas conventional nodal staging was not. An alternative staging strategy incorporating depth of invasion and lymph node density performs better than conventional TNM staging in predicting survival. Conclusion Our data suggest that lymph node density is a reliable and applicable predictor of prognosis in patients with tongue SCC.

AB - Background The prognostic significance of lymph node density in oral squamous cell carcinoma (OSCC) has been well recognized. However, its use in a specific subsite of the tongue has not been evaluated. The purpose of this study was to determine the prognostic significance of lymph node density in tongue squamous cell carcinoma (SCC). Methods A retrospective analysis of 99 patients with tongue SCC who underwent primary curative resection and neck dissection was conducted. Overall survival (OS) and disease-specific survival (DSS) was used to evaluate the prognostic significance of lymph node density. Results Lymph node density (using a cutoff of 0.06) was shown to be an independent predictor of OS and DSS. The impact of lymph node density on OS and DSS remained significant on multivariate analysis, whereas conventional nodal staging was not. An alternative staging strategy incorporating depth of invasion and lymph node density performs better than conventional TNM staging in predicting survival. Conclusion Our data suggest that lymph node density is a reliable and applicable predictor of prognosis in patients with tongue SCC.

KW - depth of invasion

KW - head and neck cancer

KW - lymph node ratio

KW - oral squamous cell carcinoma (OSCC)

KW - staging

KW - tongue cancer

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DO - 10.1002/hed.24113

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AN - SCOPUS:84973505643

SN - 1043-3074

VL - 38 Suppl 1

SP - E859-E866

JO - Head and Neck

JF - Head and Neck

ER -

Prognostic significance of lymph node density in squamous cell carcinoma of the tongue

Abstract

Keywords

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