Prognostic value of wingless-type proteins in non-small cell lung cancer patients: a meta-analysis

Jiajia Jin, Ping Zhan, Hong Qian, Xiaoxia Wang, Masaru Katoh, Kevin Phan, Jin-Haeng Chung, Tangfeng Lv*, Yong Song, AME Lung Cancer Collaborative Group

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Background: Wingless-type protein (Wnt) signaling pathway plays a crucial role in the development ofhuman malignancies, such as epithelial-to-mesenchymal transition (EMT) and the maintenance of cancerstem cells (CSCs). Several studies have shown that the expression levels of Wnt proteins, ligands of Wntsignaling pathway, are related to clinical outcomes of non-small cell lung cancer (NSCLC) patients. Thismeta-analysis aimed to assess the prognostic value of Wnts proteins in patients with NSCLC. Methods: A multiple electronic literature search was conducted to identify all articles referring to theprognostic value of Wnt proteins in patients of NSCLC up to July 2016. Eligible studies were included in ameta-analysis in order to summarize the extracted data in terms of pooled hazard ratios (HRs) and their 95%confidence intervals (95% CIs).Results: Ten studies published between 2005 and 2015 were eligible for this meta-analysis. The totalnumber of patients included was 1,805. The combined HR for all eligible studies evaluating the overallsurvival (OS) of NSCLC patients with positive Wnt expression was 1.60 (95% CI: 1.39-1.84). The subgroupanalysis showed both Wnt1 and Wnt5a are associated with clinical outcome of NSCLC patients. Conclusions: Overexpression of Wnt proteins, as well as Wnt1 or Wnt5a alone, was markedly associatedwith adverse OS in lung cancer patients, suggesting that Wnts may act as a prognostic marker amongNSCLCs.

Original languageEnglish
Pages (from-to)436-442
Number of pages7
JournalTranslational Lung Cancer Research
Issue number4
Publication statusPublished - 1 Aug 2016


  • Meta-analysis
  • Non-small cell lung cancer (NSCLC)
  • Precision medicine
  • Prognostic significance
  • Wingless-type protein (Wnt)


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