TY - JOUR
T1 - Prognostic value of wingless-type proteins in non-small cell lung cancer patients
T2 - a meta-analysis
AU - Jin, Jiajia
AU - Zhan, Ping
AU - Qian, Hong
AU - Wang, Xiaoxia
AU - Katoh, Masaru
AU - Phan, Kevin
AU - Chung, Jin-Haeng
AU - Lv, Tangfeng
AU - Song, Yong
AU - AME Lung Cancer Collaborative Group
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Background: Wingless-type protein (Wnt) signaling pathway plays a crucial role in the development ofhuman malignancies, such as epithelial-to-mesenchymal transition (EMT) and the maintenance of cancerstem cells (CSCs). Several studies have shown that the expression levels of Wnt proteins, ligands of Wntsignaling pathway, are related to clinical outcomes of non-small cell lung cancer (NSCLC) patients. Thismeta-analysis aimed to assess the prognostic value of Wnts proteins in patients with NSCLC. Methods: A multiple electronic literature search was conducted to identify all articles referring to theprognostic value of Wnt proteins in patients of NSCLC up to July 2016. Eligible studies were included in ameta-analysis in order to summarize the extracted data in terms of pooled hazard ratios (HRs) and their 95%confidence intervals (95% CIs).Results: Ten studies published between 2005 and 2015 were eligible for this meta-analysis. The totalnumber of patients included was 1,805. The combined HR for all eligible studies evaluating the overallsurvival (OS) of NSCLC patients with positive Wnt expression was 1.60 (95% CI: 1.39-1.84). The subgroupanalysis showed both Wnt1 and Wnt5a are associated with clinical outcome of NSCLC patients. Conclusions: Overexpression of Wnt proteins, as well as Wnt1 or Wnt5a alone, was markedly associatedwith adverse OS in lung cancer patients, suggesting that Wnts may act as a prognostic marker amongNSCLCs.
AB - Background: Wingless-type protein (Wnt) signaling pathway plays a crucial role in the development ofhuman malignancies, such as epithelial-to-mesenchymal transition (EMT) and the maintenance of cancerstem cells (CSCs). Several studies have shown that the expression levels of Wnt proteins, ligands of Wntsignaling pathway, are related to clinical outcomes of non-small cell lung cancer (NSCLC) patients. Thismeta-analysis aimed to assess the prognostic value of Wnts proteins in patients with NSCLC. Methods: A multiple electronic literature search was conducted to identify all articles referring to theprognostic value of Wnt proteins in patients of NSCLC up to July 2016. Eligible studies were included in ameta-analysis in order to summarize the extracted data in terms of pooled hazard ratios (HRs) and their 95%confidence intervals (95% CIs).Results: Ten studies published between 2005 and 2015 were eligible for this meta-analysis. The totalnumber of patients included was 1,805. The combined HR for all eligible studies evaluating the overallsurvival (OS) of NSCLC patients with positive Wnt expression was 1.60 (95% CI: 1.39-1.84). The subgroupanalysis showed both Wnt1 and Wnt5a are associated with clinical outcome of NSCLC patients. Conclusions: Overexpression of Wnt proteins, as well as Wnt1 or Wnt5a alone, was markedly associatedwith adverse OS in lung cancer patients, suggesting that Wnts may act as a prognostic marker amongNSCLCs.
KW - Meta-analysis
KW - Non-small cell lung cancer (NSCLC)
KW - Precision medicine
KW - Prognostic significance
KW - Wingless-type protein (Wnt)
UR - http://www.scopus.com/inward/record.url?scp=84984617635&partnerID=8YFLogxK
U2 - 10.21037/tlcr.2016.08.08
DO - 10.21037/tlcr.2016.08.08
M3 - Article
C2 - 27652206
AN - SCOPUS:84984617635
SN - 2218-6751
VL - 5
SP - 436
EP - 442
JO - Translational Lung Cancer Research
JF - Translational Lung Cancer Research
IS - 4
ER -