TY - JOUR
T1 - Progress and promise towards safe induced pluripotent stem cells for therapy
AU - Seifinejad, Ali
AU - Tabebordbar, Mohammadsharif
AU - Baharvand, Hossein
AU - Boyer, Laurie A.
AU - Salekdeh, Ghasem Hosseini
PY - 2010/6/1
Y1 - 2010/6/1
N2 - The recent generation of induced pluripotent stem cells (iPSCs) from somatic cells provides an invaluable resource for drug or toxicology screening, medical research, and patient-specific cell therapy. However, there are currently a number of obstacles including virus integration and the genetic alteration of iPSCs that will need to be overcome before these cells may be considered safe for clinical applications. Here, we highlight the potential and challenges of iPSC research and review advances in reprogramming methods that have rapidly moved the field closer to realizing the goal of generating safe iPSCs for transplantation.
AB - The recent generation of induced pluripotent stem cells (iPSCs) from somatic cells provides an invaluable resource for drug or toxicology screening, medical research, and patient-specific cell therapy. However, there are currently a number of obstacles including virus integration and the genetic alteration of iPSCs that will need to be overcome before these cells may be considered safe for clinical applications. Here, we highlight the potential and challenges of iPSC research and review advances in reprogramming methods that have rapidly moved the field closer to realizing the goal of generating safe iPSCs for transplantation.
KW - Cell therapy
KW - Embryonic stem cells
KW - Induced pluripotent stem cells
KW - iPSCs
KW - Regenerative medicine
UR - http://www.scopus.com/inward/record.url?scp=77953914634&partnerID=8YFLogxK
U2 - 10.1007/s12015-010-9121-x
DO - 10.1007/s12015-010-9121-x
M3 - Review article
C2 - 20180049
AN - SCOPUS:77953914634
SN - 1550-8943
VL - 6
SP - 297
EP - 306
JO - Stem Cell Reviews and Reports
JF - Stem Cell Reviews and Reports
IS - 2
ER -