Progress on COMPARE

a randomised controlled trial comparing constraint-induced and multi-modal aphasia therapy to usual care in people with chronic aphasia

M. Rose, L. Nickels, M. Hurley, D. Copland, L. Togher, M. Meinzer, T. Rai, E. Godecke, J. Kim, D. Cadilhac, J. Pierce, A. Foster

    Research output: Contribution to journalMeeting abstract


    Background/Aims: Chronic post-stroke aphasia impacts 30% of stroke survivors. The aim of this trial is to determine whether two contrasting, intensive treatments, Constraint Induced Aphasia Therapy (CIAT) and Multi-Modal Aphasia Therapy (M-MAT), are superior and cost-effective than usual care (UC). The variable response to these therapies may be accounted for by aphasia severity and co-occurring cognitive problems. Methods: 3-arm prospective, single-blinded, randomised controlled trial. Primary end point at 3 months post-treatment. Participants (n = 198) are randomised to CIAT, M-MAT or UC. CIAT and M-MAT both focus on intensive speech practice (30 hours over 2 weeks) using interactive game formats. However, while M-MAT involves gesture, writing, and drawing cues, CIAT focuses on speech alone. UC is usual health service-based aphasia therapy. Primary outcome immediately post treatment is the Aphasia Quotient of the Western Aphasia Battery. Secondary outcomes at 3-month follow-up include measures of connected speech, multi-modal communication, and quality of life. Participant cognitive and linguistic predictors of treatment response are identified. Re-randomised UC participants will undertake a less intense schedule (30 hours over 5 weeks) in a nested sub-study exploring the impact of treatment intensity on outcomes. A full cost-effectiveness analysis will be undertaken. Results: The trial is underway: ethics approval, trial registration, and database are established. Recruitment from five Australian states has commenced. Conclusions: This trial will determine if there is a significant therapeutic effect of, and variable response to treatment types in chronic aphasia. Essential economic evaluation information for service delivery standards for aphasia rehabilitation will be described.
    Original languageEnglish
    Pages (from-to)17-17
    Number of pages1
    JournalSmart Strokes 2016 Conference : abstracts
    Issue numberS1
    Publication statusPublished - Aug 2016
    EventSmart Strokes (2016) - Canberra, ACT, Australia
    Duration: 25 Aug 201626 Aug 2016

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