Progressive white matter injury in preclinical Dutch cerebral amyloid angiopathy

Zahra Shirzadi; Wai Ying W. Yau; Stephanie A. Schultz; Aaron P. Schultz; Matthew R. Scott; Maged Goubran; Parisa Mojiri-Forooshani; Nelly Joseph-Mathurin; Kejal Kantarci; Greg Preboske; Marieke J. H. Wermer; Clifford Jack; Tammie Benzinger; Kevin Taddei; Hamid R. Sohrabi; Reisa A. Sperling; Keith A. Johnson; Randall J. Bateman; Ralph N. Martins; Steven M. Greenberg; Jasmeer P. Chhatwal; DIAN Investigators

doi:10.1002/ana.26429

Progressive white matter injury in preclinical Dutch cerebral amyloid angiopathy

Zahra Shirzadi, Wai Ying W. Yau, Stephanie A. Schultz, Aaron P. Schultz, Matthew R. Scott, Maged Goubran, Parisa Mojiri-Forooshani, Nelly Joseph-Mathurin, Kejal Kantarci, Greg Preboske, Marieke J. H. Wermer, Clifford Jack, Tammie Benzinger, Kevin Taddei, Hamid R. Sohrabi, Reisa A. Sperling, Keith A. Johnson, Randall J. Bateman, Ralph N. Martins, Steven M. GreenbergJasmeer P. Chhatwal^*, DIAN Investigators

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Autosomal-dominant, Dutch-type cerebral amyloid angiopathy (D-CAA) offers a unique opportunity to develop biomarkers for pre-symptomatic cerebral amyloid angiopathy (CAA). We hypothesized that neuroimaging measures of white matter injury would be present and progressive in D-CAA prior to hemorrhagic lesions or symptomatic hemorrhage. In a longitudinal cohort of D-CAA carriers and non-carriers, we observed divergence of white matter injury measures between D-CAA carriers and non-carriers prior to the appearance of cerebral microbleeds and >14 years before the average age of first symptomatic hemorrhage. These results indicate that white matter disruption measures may be valuable cross-sectional and longitudinal biomarkers of D-CAA progression.

Original language	English
Pages (from-to)	358-363
Number of pages	6
Journal	Annals of Neurology
Volume	92
Issue number	3
DOIs	https://doi.org/10.1002/ana.26429
Publication status	Published - Sept 2022
Externally published	Yes

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Shirzadi, Z., Yau, W. Y. W., Schultz, S. A., Schultz, A. P., Scott, M. R., Goubran, M., Mojiri-Forooshani, P., Joseph-Mathurin, N., Kantarci, K., Preboske, G., Wermer, M. J. H., Jack, C., Benzinger, T., Taddei, K., Sohrabi, H. R., Sperling, R. A., Johnson, K. A., Bateman, R. J., Martins, R. N., ... DIAN Investigators (2022). Progressive white matter injury in preclinical Dutch cerebral amyloid angiopathy. Annals of Neurology, 92(3), 358-363. https://doi.org/10.1002/ana.26429

@article{d0552005302e44e19b7896892942e65d,

title = "Progressive white matter injury in preclinical Dutch cerebral amyloid angiopathy",

abstract = "Autosomal-dominant, Dutch-type cerebral amyloid angiopathy (D-CAA) offers a unique opportunity to develop biomarkers for pre-symptomatic cerebral amyloid angiopathy (CAA). We hypothesized that neuroimaging measures of white matter injury would be present and progressive in D-CAA prior to hemorrhagic lesions or symptomatic hemorrhage. In a longitudinal cohort of D-CAA carriers and non-carriers, we observed divergence of white matter injury measures between D-CAA carriers and non-carriers prior to the appearance of cerebral microbleeds and >14 years before the average age of first symptomatic hemorrhage. These results indicate that white matter disruption measures may be valuable cross-sectional and longitudinal biomarkers of D-CAA progression.",

author = "Zahra Shirzadi and Yau, {Wai Ying W.} and Schultz, {Stephanie A.} and Schultz, {Aaron P.} and Scott, {Matthew R.} and Maged Goubran and Parisa Mojiri-Forooshani and Nelly Joseph-Mathurin and Kejal Kantarci and Greg Preboske and Wermer, {Marieke J. H.} and Clifford Jack and Tammie Benzinger and Kevin Taddei and Sohrabi, {Hamid R.} and Sperling, {Reisa A.} and Johnson, {Keith A.} and Bateman, {Randall J.} and Martins, {Ralph N.} and Greenberg, {Steven M.} and Chhatwal, {Jasmeer P.} and {DIAN Investigators}",

year = "2022",

month = sep,

doi = "10.1002/ana.26429",

language = "English",

volume = "92",

pages = "358--363",

journal = "Annals of Neurology",

issn = "0364-5134",

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}

Shirzadi, Z, Yau, WYW, Schultz, SA, Schultz, AP, Scott, MR, Goubran, M, Mojiri-Forooshani, P, Joseph-Mathurin, N, Kantarci, K, Preboske, G, Wermer, MJH, Jack, C, Benzinger, T, Taddei, K, Sohrabi, HR, Sperling, RA, Johnson, KA, Bateman, RJ, Martins, RN, Greenberg, SM, Chhatwal, JP & DIAN Investigators 2022, 'Progressive white matter injury in preclinical Dutch cerebral amyloid angiopathy', Annals of Neurology, vol. 92, no. 3, pp. 358-363. https://doi.org/10.1002/ana.26429

TY - JOUR

T1 - Progressive white matter injury in preclinical Dutch cerebral amyloid angiopathy

AU - Shirzadi, Zahra

AU - Yau, Wai Ying W.

AU - Schultz, Stephanie A.

AU - Schultz, Aaron P.

AU - Scott, Matthew R.

AU - Goubran, Maged

AU - Mojiri-Forooshani, Parisa

AU - Joseph-Mathurin, Nelly

AU - Kantarci, Kejal

AU - Preboske, Greg

AU - Wermer, Marieke J. H.

AU - Jack, Clifford

AU - Benzinger, Tammie

AU - Taddei, Kevin

AU - Sohrabi, Hamid R.

AU - Sperling, Reisa A.

AU - Johnson, Keith A.

AU - Bateman, Randall J.

AU - Martins, Ralph N.

AU - Greenberg, Steven M.

AU - Chhatwal, Jasmeer P.

AU - DIAN Investigators

PY - 2022/9

Y1 - 2022/9

N2 - Autosomal-dominant, Dutch-type cerebral amyloid angiopathy (D-CAA) offers a unique opportunity to develop biomarkers for pre-symptomatic cerebral amyloid angiopathy (CAA). We hypothesized that neuroimaging measures of white matter injury would be present and progressive in D-CAA prior to hemorrhagic lesions or symptomatic hemorrhage. In a longitudinal cohort of D-CAA carriers and non-carriers, we observed divergence of white matter injury measures between D-CAA carriers and non-carriers prior to the appearance of cerebral microbleeds and >14 years before the average age of first symptomatic hemorrhage. These results indicate that white matter disruption measures may be valuable cross-sectional and longitudinal biomarkers of D-CAA progression.

AB - Autosomal-dominant, Dutch-type cerebral amyloid angiopathy (D-CAA) offers a unique opportunity to develop biomarkers for pre-symptomatic cerebral amyloid angiopathy (CAA). We hypothesized that neuroimaging measures of white matter injury would be present and progressive in D-CAA prior to hemorrhagic lesions or symptomatic hemorrhage. In a longitudinal cohort of D-CAA carriers and non-carriers, we observed divergence of white matter injury measures between D-CAA carriers and non-carriers prior to the appearance of cerebral microbleeds and >14 years before the average age of first symptomatic hemorrhage. These results indicate that white matter disruption measures may be valuable cross-sectional and longitudinal biomarkers of D-CAA progression.

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AN - SCOPUS:85133769255

SN - 0364-5134

VL - 92

SP - 358

EP - 363

JO - Annals of Neurology

JF - Annals of Neurology

IS - 3

ER -

Progressive white matter injury in preclinical Dutch cerebral amyloid angiopathy

Abstract

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