Abstract
Purpose: To investigate whether there are functional changes in the retina in multiple sclerosis (MS) patients measured by full-field electroretinography (ERG).
Method: 27 MS patients with unilateral optic neuritis (ON) history (>2 years after the acute ON episode) and 29 age- and sex- matched normal subjects were enrolled in this study. ERG recordings were carried out as per the ISCEV standard. For dark-adapted ERGs, rod and combined rod-cone responses were recorded to white flashes with stimulus strengths of 0.01 (DA 0.01), 3.0 (DA 3.0 and oscillatory potentials) and 12.0 (DA 12.0) cdms-2, respectively, after 20min dark-adaptation; For light-adapted ERGs, after patients were exposed to 30 cdm-2 background luminance for 10 min, single-flash cone response (LA 3.0) and 30 Hz flicker were recorded accordingly. ERG recordings were performed on MS patients annually for 3 years.
Results: Latency delay of ERG waves was found in both ON and non-ON eyes in MS but more severe in the eyes with a history of ON. There was a mild but significant delay in a-wave latency in DA 3.0 (ON:18.7+/-0.6 ms; non-ON:18.1+/-0.5 ms; normal: 16.6+/-0.3 ms; P<0.01). Similarly, a prolonged b-wave implicit time was also observed in MS in LA 3.0 (ON:30.4+/-0.2 ms; non-NO:30.4+/-0.2 ms; normal: 29.7+/-0.2 ms; P<0.01). Prolongation of the implicit time of ERG waves significantly improved over time during the 3-year follow-up period. No abnormalities were found in the ERG amplitudes.
Conclusion: This study suggests there is mild retinal dysfunction in multiple sclerosis, which may be due to subclinical autoimmune activity.
Method: 27 MS patients with unilateral optic neuritis (ON) history (>2 years after the acute ON episode) and 29 age- and sex- matched normal subjects were enrolled in this study. ERG recordings were carried out as per the ISCEV standard. For dark-adapted ERGs, rod and combined rod-cone responses were recorded to white flashes with stimulus strengths of 0.01 (DA 0.01), 3.0 (DA 3.0 and oscillatory potentials) and 12.0 (DA 12.0) cdms-2, respectively, after 20min dark-adaptation; For light-adapted ERGs, after patients were exposed to 30 cdm-2 background luminance for 10 min, single-flash cone response (LA 3.0) and 30 Hz flicker were recorded accordingly. ERG recordings were performed on MS patients annually for 3 years.
Results: Latency delay of ERG waves was found in both ON and non-ON eyes in MS but more severe in the eyes with a history of ON. There was a mild but significant delay in a-wave latency in DA 3.0 (ON:18.7+/-0.6 ms; non-ON:18.1+/-0.5 ms; normal: 16.6+/-0.3 ms; P<0.01). Similarly, a prolonged b-wave implicit time was also observed in MS in LA 3.0 (ON:30.4+/-0.2 ms; non-NO:30.4+/-0.2 ms; normal: 29.7+/-0.2 ms; P<0.01). Prolongation of the implicit time of ERG waves significantly improved over time during the 3-year follow-up period. No abnormalities were found in the ERG amplitudes.
Conclusion: This study suggests there is mild retinal dysfunction in multiple sclerosis, which may be due to subclinical autoimmune activity.
| Original language | English |
|---|---|
| Article number | 0902 |
| Pages (from-to) | 29-30 |
| Number of pages | 2 |
| Journal | Clinical and Experimental Ophthalmology |
| Volume | 43 |
| Issue number | S1 |
| Publication status | Published - Oct 2015 |
| Event | Annual Scientific Congress of the Royal Australian and New Zealand College of Ophthalmologists (47th : 2015) - Wellington, New Zealand Duration: 31 Oct 2015 → 4 Nov 2015 |