Prolonged a-wave and b-wave implicit time in full-field electroretinography in multiple sclerosis

Yuyi You, Stuart Graham, Alexander Klistorner

    Research output: Contribution to journalMeeting abstract


    Purpose: To investigate whether there are functional changes in the retina in multiple sclerosis (MS) patients measured by full-field electroretinography (ERG).
    Method: 27 MS patients with unilateral optic neuritis (ON) history (>2 years after the acute ON episode) and 29 age- and sex- matched normal subjects were enrolled in this study. ERG recordings were carried out as per the ISCEV standard. For dark-adapted ERGs, rod and combined rod-cone responses were recorded to white flashes with stimulus strengths of 0.01 (DA 0.01), 3.0 (DA 3.0 and oscillatory potentials) and 12.0 (DA 12.0) cdms-2, respectively, after 20min dark-adaptation; For light-adapted ERGs, after patients were exposed to 30 cdm-2 background luminance for 10 min, single-flash cone response (LA 3.0) and 30 Hz flicker were recorded accordingly. ERG recordings were performed on MS patients annually for 3 years.
    Results: Latency delay of ERG waves was found in both ON and non-ON eyes in MS but more severe in the eyes with a history of ON. There was a mild but significant delay in a-wave latency in DA 3.0 (ON:18.7+/-0.6 ms; non-ON:18.1+/-0.5 ms; normal: 16.6+/-0.3 ms; P<0.01). Similarly, a prolonged b-wave implicit time was also observed in MS in LA 3.0 (ON:30.4+/-0.2 ms; non-NO:30.4+/-0.2 ms; normal: 29.7+/-0.2 ms; P<0.01). Prolongation of the implicit time of ERG waves significantly improved over time during the 3-year follow-up period. No abnormalities were found in the ERG amplitudes.
    Conclusion: This study suggests there is mild retinal dysfunction in multiple sclerosis, which may be due to subclinical autoimmune activity.
    Original languageEnglish
    Article number0902
    Pages (from-to)29-30
    Number of pages2
    JournalClinical and Experimental Ophthalmology
    Issue numberS1
    Publication statusPublished - Oct 2015
    EventAnnual Scientific Congress of the Royal Australian and New Zealand College of Ophthalmologists (47th : 2015) - Wellington, New Zealand
    Duration: 31 Oct 20154 Nov 2015


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