TY - JOUR
T1 - Promotion of cellular NAD+ anabolism
T2 - therapeutic potential for oxidative stress in ageing and Alzheimer's disease
AU - Braidy, Nady
AU - Guillemin, Gilles
AU - Grant, Ross
PY - 2008/9
Y1 - 2008/9
N2 - Oxidative imbalance is a prominent feature in Alzheimer's disease and ageing. Increased levels of reactive oxygen species (ROS) can result in disordered cellular metabolism due to lipid peroxidation, protein-cross linking, DNA damage and the depletion of nicotinamide adenine dinucleotide (NAD+). NAD+ is a ubiquitous pyridine nucleotide that plays an essential role in important biological reactions, from ATP production and secondary messenger signalling, to transcriptional regulation and DNA repair. Chronic oxidative stress may be associated with NAD+ depletion and a subsequent decrease in metabolic regulation and cell viability. Hence, therapies targeted toward maintaining intracellular NAD+ pools may prove efficacious in the protection of age-dependent cellular damage, in general, and neurodegeneration in chronic central nervous system inflammatory diseases such as Alzheimer's disease, in particular.
AB - Oxidative imbalance is a prominent feature in Alzheimer's disease and ageing. Increased levels of reactive oxygen species (ROS) can result in disordered cellular metabolism due to lipid peroxidation, protein-cross linking, DNA damage and the depletion of nicotinamide adenine dinucleotide (NAD+). NAD+ is a ubiquitous pyridine nucleotide that plays an essential role in important biological reactions, from ATP production and secondary messenger signalling, to transcriptional regulation and DNA repair. Chronic oxidative stress may be associated with NAD+ depletion and a subsequent decrease in metabolic regulation and cell viability. Hence, therapies targeted toward maintaining intracellular NAD+ pools may prove efficacious in the protection of age-dependent cellular damage, in general, and neurodegeneration in chronic central nervous system inflammatory diseases such as Alzheimer's disease, in particular.
UR - http://www.scopus.com/inward/record.url?scp=55249118587&partnerID=8YFLogxK
U2 - 10.1007/BF03033501
DO - 10.1007/BF03033501
M3 - Article
C2 - 18522897
AN - SCOPUS:55249118587
SN - 1029-8428
VL - 13
SP - 173
EP - 184
JO - Neurotoxicity Research
JF - Neurotoxicity Research
IS - 3-4
ER -