Prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus: design and rationale of a placebo-controlled randomized multicenter trial [ISRCTN71132784]

Behzad Eftekhar; Mohammad Ghodsi; Azar Hadadi; Mousa Taghipoor; Samira Zabihyan Sigarchi; Vafa Rahimi-Movaghar; Ehsan Sherafat Kazemzadeh; Babak Esmaeeli; Farideh Nejat; Alireza Yalda; Ebrahim Ketabchi

doi:10.1186/1745-6215-7-2

Prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus: design and rationale of a placebo-controlled randomized multicenter trial [ISRCTN71132784]

Behzad Eftekhar, Mohammad Ghodsi, Azar Hadadi, Mousa Taghipoor, Samira Zabihyan Sigarchi, Vafa Rahimi-Movaghar, Ehsan Sherafat Kazemzadeh, Babak Esmaeeli, Farideh Nejat, Alireza Yalda, Ebrahim Ketabchi

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

BACKGROUND: The purpose of this study is to compare the efficacy of prophylactic antibiotic for prevention of meningitis in acute traumatic pneumocephalus patients.

METHODS: In this prospective, randomized controlled clinical trial, 200 selected head injury patients with traumatic pneumocephalus are randomly assigned to receive intravenous antibiotics (2 grams Ceftriaxone twice a day), oral antibiotics (Azithromycin) or placebo for at least 7 days after trauma. The patients will be followed for one month posttrauma.

CONCLUSION: The authors hope that this study helps clarifying the effectiveness and indications of antibiotics in prevention of meningitis in traumatic pneumocephalus after head injury and in specific subgroup of these patients.

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	Trials
Volume	7
Issue number	1
DOIs	https://doi.org/10.1186/1745-6215-7-2
Publication status	Published - 18 Jan 2006
Externally published	Yes

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Journal Article

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10.1186/1745-6215-7-2

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Eftekhar, B., Ghodsi, M., Hadadi, A., Taghipoor, M., Sigarchi, S. Z., Rahimi-Movaghar, V., Kazemzadeh, E. S., Esmaeeli, B., Nejat, F., Yalda, A., & Ketabchi, E. (2006). Prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus: design and rationale of a placebo-controlled randomized multicenter trial [ISRCTN71132784]. Trials, 7(1), 1-4. https://doi.org/10.1186/1745-6215-7-2

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abstract = "BACKGROUND: The purpose of this study is to compare the efficacy of prophylactic antibiotic for prevention of meningitis in acute traumatic pneumocephalus patients.METHODS: In this prospective, randomized controlled clinical trial, 200 selected head injury patients with traumatic pneumocephalus are randomly assigned to receive intravenous antibiotics (2 grams Ceftriaxone twice a day), oral antibiotics (Azithromycin) or placebo for at least 7 days after trauma. The patients will be followed for one month posttrauma.CONCLUSION: The authors hope that this study helps clarifying the effectiveness and indications of antibiotics in prevention of meningitis in traumatic pneumocephalus after head injury and in specific subgroup of these patients.",

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author = "Behzad Eftekhar and Mohammad Ghodsi and Azar Hadadi and Mousa Taghipoor and Sigarchi, {Samira Zabihyan} and Vafa Rahimi-Movaghar and Kazemzadeh, {Ehsan Sherafat} and Babak Esmaeeli and Farideh Nejat and Alireza Yalda and Ebrahim Ketabchi",

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Eftekhar, B, Ghodsi, M, Hadadi, A, Taghipoor, M, Sigarchi, SZ, Rahimi-Movaghar, V, Kazemzadeh, ES, Esmaeeli, B, Nejat, F, Yalda, A & Ketabchi, E 2006, 'Prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus: design and rationale of a placebo-controlled randomized multicenter trial [ISRCTN71132784]', Trials, vol. 7, no. 1, pp. 1-4. https://doi.org/10.1186/1745-6215-7-2

TY - JOUR

T1 - Prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus

T2 - design and rationale of a placebo-controlled randomized multicenter trial [ISRCTN71132784]

AU - Eftekhar, Behzad

AU - Ghodsi, Mohammad

AU - Hadadi, Azar

AU - Taghipoor, Mousa

AU - Sigarchi, Samira Zabihyan

AU - Rahimi-Movaghar, Vafa

AU - Kazemzadeh, Ehsan Sherafat

AU - Esmaeeli, Babak

AU - Nejat, Farideh

AU - Yalda, Alireza

AU - Ketabchi, Ebrahim

PY - 2006/1/18

Y1 - 2006/1/18

N2 - BACKGROUND: The purpose of this study is to compare the efficacy of prophylactic antibiotic for prevention of meningitis in acute traumatic pneumocephalus patients.METHODS: In this prospective, randomized controlled clinical trial, 200 selected head injury patients with traumatic pneumocephalus are randomly assigned to receive intravenous antibiotics (2 grams Ceftriaxone twice a day), oral antibiotics (Azithromycin) or placebo for at least 7 days after trauma. The patients will be followed for one month posttrauma.CONCLUSION: The authors hope that this study helps clarifying the effectiveness and indications of antibiotics in prevention of meningitis in traumatic pneumocephalus after head injury and in specific subgroup of these patients.

AB - BACKGROUND: The purpose of this study is to compare the efficacy of prophylactic antibiotic for prevention of meningitis in acute traumatic pneumocephalus patients.METHODS: In this prospective, randomized controlled clinical trial, 200 selected head injury patients with traumatic pneumocephalus are randomly assigned to receive intravenous antibiotics (2 grams Ceftriaxone twice a day), oral antibiotics (Azithromycin) or placebo for at least 7 days after trauma. The patients will be followed for one month posttrauma.CONCLUSION: The authors hope that this study helps clarifying the effectiveness and indications of antibiotics in prevention of meningitis in traumatic pneumocephalus after head injury and in specific subgroup of these patients.

KW - Journal Article

U2 - 10.1186/1745-6215-7-2

DO - 10.1186/1745-6215-7-2

M3 - Article

C2 - 16542035

SN - 1745-6215

VL - 7

SP - 1

EP - 4

JO - Trials

JF - Trials

IS - 1

ER -

Prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus: design and rationale of a placebo-controlled randomized multicenter trial [ISRCTN71132784]

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