Prospective quality of life assessment between treatment groups for oral cavity squamous cell carcinoma

Sydney Ch'ng*, Justine Oates, Kan Gao, Kerwyn Foo, Sarah Davies, Markus Brunner, Jonathan R. Clark

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Background. Postoperative radiation therapy (PORT) is frequently recommended to improve survival outcome. The effect of PORT-associated morbidity on patients' quality of life (QOL) is, however, not well established. This study assessed the effect of PORT on medium-term (ie, at 6 months) QOL in patients with oral cavity squamous cell carcinoma (SCC). Methods. Patients completed the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) and Quality of Life Questionnaire Core Head and Neck 35 (QLQ-HN35) at initial presentation, and at 3-, 6-, and 12-month follow-up. Baseline QOL scores were adjusted for using analysis of covariance (ANCOVA). Results. Global health status (mean difference = 13.3; p =.042) and xerostomia (mean difference = 35.4; p =.003) were significantly worse at 6 months in patients who received PORT compared to those treated with surgery alone. Conclusion. The survival advantage needs to be balanced against increased treatment toxicity. PORT is associated with reduced global health status, increased xerostomia, and marginally increased levels of fatigue at 6 months posttreatment for oral cavity cancer.

Original languageEnglish
Pages (from-to)834-840
Number of pages7
JournalHead and Neck
Volume36
Issue number6
DOIs
Publication statusPublished - Jun 2014
Externally publishedYes

Keywords

  • oral cavity
  • quality of life
  • radiotherapy
  • squamous cell carcinoma

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