This article reviews the prospects for a small-molecule agonist of the growth hormone receptor in the light of current successes in identifying small agonist molecules for other homomeric class I cytokine receptors. A variety of mutagenic analyses on both hormone and receptor, studies with monoclonal antibody agonists of the GH receptor, and the use of a constitutively dimerized GH receptor chimera which displays constitutive activity lead us to believe that such a development is possible. However, it is likely that a precise alignment of the lower cytokine receptor homology domains will be necessary in order to facilitate cross-activation of cytoplasmic Janus kinases bound to Box 1.
|Number of pages||5|
|Journal||Letters in Peptide Science|
|Publication status||Published - 1999|
- Cytokine receptor
- Growth hormone
- Small mimetic