Prospects for a small molecule able to induce somatic growth through the growth hormone receptor

M. J. Waters*, S. N. Behncken, B. Conway-Campbell, J. E. Rowland, C. M. Chen, S. W. Rowlinson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

This article reviews the prospects for a small-molecule agonist of the growth hormone receptor in the light of current successes in identifying small agonist molecules for other homomeric class I cytokine receptors. A variety of mutagenic analyses on both hormone and receptor, studies with monoclonal antibody agonists of the GH receptor, and the use of a constitutively dimerized GH receptor chimera which displays constitutive activity lead us to believe that such a development is possible. However, it is likely that a precise alignment of the lower cytokine receptor homology domains will be necessary in order to facilitate cross-activation of cytoplasmic Janus kinases bound to Box 1.

Original languageEnglish
Pages (from-to)353-357
Number of pages5
JournalLetters in Peptide Science
Volume6
Issue number5-6
Publication statusPublished - 1999
Externally publishedYes

Keywords

  • Cytokine receptor
  • Dimerization
  • Growth hormone
  • Mutagenesis
  • Small mimetic

Fingerprint Dive into the research topics of 'Prospects for a small molecule able to induce somatic growth through the growth hormone receptor'. Together they form a unique fingerprint.

Cite this