Protein-protein interactions and prediction: a comprehensive overview

Gopichandran Sowmya, Shoba Ranganathan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Molecular function in cellular processes is governed by protein-Protein interactions (PPIs) within biological networks. Selective yet specific association of these protein partners contributes to diverse functionality such as catalysis, regulation, assembly, immunity, and inhibition in a cell. Therefore, understanding the principles of protein-Protein association has been of immense interest for several decades. We provide an overview of the experimental methods used to determine PPIs and the key databases archiving this information. Structural and functional information of existing protein complexes confers knowledge on the principles of PPI, based on which a classification scheme for PPIs is then introduced. Obtaining high-quality non-redundant datasets of protein complexes for interaction characterisation is an essential step towards deciphering their underlying binding principles. Analysis of physicochemical features and their documentation has enhanced our understanding of the molecular basis of protein-Protein association. We describe the diverse datasets created/collected by various groups and their key findings inferring distinguishing features. The currently available interface databases and prediction servers have also been compiled.

Original languageEnglish
Pages (from-to)779-789
Number of pages11
JournalProtein and peptide letters
Volume21
Issue number8
DOIs
Publication statusPublished - 2014

Keywords

  • Binding sites
  • Interface features
  • Prediction
  • Protein complexes
  • Protein-Protein interactions

Fingerprint

Dive into the research topics of 'Protein-protein interactions and prediction: a comprehensive overview'. Together they form a unique fingerprint.

Cite this