Protein S-100 and neuropsychological functioning following severe traumatic brain injury

Sharon E. Watt, E. Arthur Shores*, Ian J. Baguley, Nicholas Dorsch, Michael R. Fearnside

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)

    Abstract

    Primary objective: To examine the relationship between serum concentrations of protein S-100β and neuropsychological functioning following severe traumatic brain injury. Design: Matched control group. Methods: Blood samples were taken within 12 hours of injury and then daily up to 7 days post-injury (n = 23). Within 2 weeks of emerging from post-traumatic amnesia (PTA), participants completed a battery of neuropsychological measures. These results were compared with a matched sample of healthy controls. Results: Early measurement of S-100 not only reflected overall brain injury severity, but also related to neuropsychological deficits, with higher serum concentrations associated with poorer performance across most cognitive domains. PTA duration, measured by the Westmead PTA Scale, was found to be the strongest predictor of S-100 concentration (R2, p<0.001). Conclusions: These findings show that measurement of serum protein S-100 may further aid in the identification of individuals with severe TBI who are likely to experience cognitive difficulties.

    Original languageEnglish
    Pages (from-to)1007-1017
    Number of pages11
    JournalBrain Injury
    Volume20
    Issue number10
    DOIs
    Publication statusPublished - Sep 2006

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