Protein tyrosine phosphatase 1B

a novel molecular target for retinal degenerative diseases

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contribution

3 Citations (Scopus)

Abstract

Protein tyrosine phosphatase 1B (PTP1B) is considered as a major negative regulator of insulin receptor (IR) signaling. IR signaling in retina has been demonstrated to be neuroprotective. Photoreceptor-specific deletion of PTP1B results in enhanced retinal IR-mediated neuroprotection indicating the importance of PTP1B as a negative regulator in the retina. Elevated levels of retinal PTP1B activity have been observed in mice lacking retinal pigment epithelium (Rpe65 -/-), a mouse model of leber congenital amaurosis (LCA-type 2), retinitis pigmentosa and diabetic retinopathy animal models. This enhanced PTP1B activity could downregulate the IR signaling which may contribute to the death of photoreceptor neurons and ultimately lead to retinal degenerations. The potential therapeutic agents that specifically reduce or inhibit the PTP1B activity could be beneficial in protecting or delaying the photoreceptor cell death in the retinal degenerative diseases.
Original languageEnglish
Title of host publicationRetinal degenerative diseases
EditorsMatthew M. LaVail, John D. Ash, Robert E. Anderson, Joe G. Hollyfield, Christian Grimm
Place of PublicationNew York
PublisherSpringer, Springer Nature
Pages829-834
Number of pages6
ISBN (Print)9781461406303
DOIs
Publication statusPublished - 2012
Externally publishedYes
EventInternational Symposium on Retinal Degenerations (14th : 2010) - Mont-tremblant, Canada
Duration: 13 Jul 201017 Jul 2010

Publication series

NameAdvances in experimental medicine and biology
PublisherSpringer
Volume723
ISSN (Print)0065-2598

Conference

ConferenceInternational Symposium on Retinal Degenerations (14th : 2010)
CityMont-tremblant, Canada
Period13/07/1017/07/10

Keywords

  • Insulin Receptor
  • Neuroprotection
  • Protein Tyrosine Phosphatase-1B
  • Retinal Degeneration
  • Rhodopsin

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  • Cite this

    Basavarajappa, D. K., Gupta, V. K., & Rajala, R. V. S. (2012). Protein tyrosine phosphatase 1B: a novel molecular target for retinal degenerative diseases. In M. M. LaVail, J. D. Ash, R. E. Anderson, J. G. Hollyfield, & C. Grimm (Eds.), Retinal degenerative diseases (pp. 829-834). (Advances in experimental medicine and biology; Vol. 723). New York: Springer, Springer Nature. https://doi.org/10.1007/978-1-4614-0631-0_106