Abstract
In this review we examine the current state of proteome analysis. There are three main issues discussed: why it is necessary to study proteomes; how proteomes can be analyzed with current technology; and how proteome analysis can be used to enhance biological research. We conclude that proteome analysis is an essential tool in the understanding of regulated biological systems. Current technology, while still mostly limited to the more abundant proteins, enables the use of proteome analysis both to establish databases of proteins present, and to perform biological assays involving measurement of multiple variables. We believe that the utility of proteome analysis in future biological research will continue to be enhanced by further improvements in analytical technology.
| Original language | English |
|---|---|
| Pages (from-to) | 1862-1871 |
| Number of pages | 10 |
| Journal | Electrophoresis |
| Volume | 19 |
| Issue number | 11 |
| Publication status | Published - Aug 1998 |
| Externally published | Yes |
Keywords
- Proteome
- Tandem mass spectrometry
- Two-dimensional polyacrylamide gel electrophoresis