Proteome analysis: Biological assay or data archive?

Paul A. Haynes, Steven P. Gygi, Daniel Figeys, Ruedi Aebersold*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

140 Citations (Scopus)

Abstract

In this review we examine the current state of proteome analysis. There are three main issues discussed: why it is necessary to study proteomes; how proteomes can be analyzed with current technology; and how proteome analysis can be used to enhance biological research. We conclude that proteome analysis is an essential tool in the understanding of regulated biological systems. Current technology, while still mostly limited to the more abundant proteins, enables the use of proteome analysis both to establish databases of proteins present, and to perform biological assays involving measurement of multiple variables. We believe that the utility of proteome analysis in future biological research will continue to be enhanced by further improvements in analytical technology.

Original languageEnglish
Pages (from-to)1862-1871
Number of pages10
JournalElectrophoresis
Volume19
Issue number11
Publication statusPublished - Aug 1998
Externally publishedYes

Keywords

  • Proteome
  • Tandem mass spectrometry
  • Two-dimensional polyacrylamide gel electrophoresis

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