TY - JOUR
T1 - Proteomic databases and tools to decipher post-translational modifications
AU - Kamath, Karthik S.
AU - Vasavada, Meghana S.
AU - Srivastava, Sanjeeva
PY - 2011/12/10
Y1 - 2011/12/10
N2 - Post-translational modifications (PTMs) are vital cellular control mechanism, which affect protein properties, including folding, conformation, activity and consequently, their functions. As a result they play a key role in various disease conditions, including cancer and diabetes. Proteomics as a rapidly growing field has witnessed tremendous advancement during the last decade, which has led to the generation of prodigious quantity of data for various organisms' proteome. PTMs being biologically and chemically dynamic process, pose greater challenges for its study. Amidst these complexities connecting the modifications with physiological and cellular cascade of events are still very challenging. Advancement in proteomic technologies such as mass spectrometry and microarray provides HT platform to study PTMs and help to decipher role of some of the very essential biological phenomenon. To enhance our understanding of various PTMs in different organisms, and to simplify the analysis of complex PTM data, many databases, software and tools have been developed. These PTM databases and tools contain crucial information and provide a valuable resource to the research community. This article intends to provide a comprehensive overview of various PTM databases, software tools, and analyze critical information available from these resources to study PTMs in various biological organisms.
AB - Post-translational modifications (PTMs) are vital cellular control mechanism, which affect protein properties, including folding, conformation, activity and consequently, their functions. As a result they play a key role in various disease conditions, including cancer and diabetes. Proteomics as a rapidly growing field has witnessed tremendous advancement during the last decade, which has led to the generation of prodigious quantity of data for various organisms' proteome. PTMs being biologically and chemically dynamic process, pose greater challenges for its study. Amidst these complexities connecting the modifications with physiological and cellular cascade of events are still very challenging. Advancement in proteomic technologies such as mass spectrometry and microarray provides HT platform to study PTMs and help to decipher role of some of the very essential biological phenomenon. To enhance our understanding of various PTMs in different organisms, and to simplify the analysis of complex PTM data, many databases, software and tools have been developed. These PTM databases and tools contain crucial information and provide a valuable resource to the research community. This article intends to provide a comprehensive overview of various PTM databases, software tools, and analyze critical information available from these resources to study PTMs in various biological organisms.
KW - Databases
KW - Glycosylation
KW - Phosphorylation
KW - Posttranslational modifications
KW - Predictors
UR - http://www.scopus.com/inward/record.url?scp=84858726212&partnerID=8YFLogxK
U2 - 10.1016/j.jprot.2011.09.014
DO - 10.1016/j.jprot.2011.09.014
M3 - Review article
C2 - 21983556
AN - SCOPUS:84858726212
SN - 1874-3919
VL - 75
SP - 127
EP - 144
JO - Journal of Proteomics
JF - Journal of Proteomics
IS - 1
ER -