Proteomics provides insights into the theranostic potential of extracellular vesicles

Morteza Abyadeh, Mehdi Alikhani, Mehdi Mirzaei, Vivek Gupta, Faezeh Shekari, Ghasem Hosseini Salekdeh*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Citations (Scopus)

Abstract

Extracellular vesicles (EVs) encompass a diverse range of membranous structures derived from cells, including exosomes and microvesicles. These vesicles are present in biological fluids and play vital roles in various physiological and pathological processes. They facilitate intercellular communication by enabling the exchange of proteins, lipids, and genetic material between cells. Understanding the cellular processes that govern EV biology is essential for unraveling their physiological and pathological functions and their potential clinical applications. Despite significant advancements in EV research in recent years, there is still much to learn about these vesicles. The advent of improved mass spectrometry (MS)-based techniques has allowed for a deeper characterization of EV protein composition, providing valuable insights into their roles in different physiological and pathological conditions. In this chapter, we provide an overview of proteomics studies conducted to identify the protein contents of EVs, which contribute to their therapeutic and pathological features. We also provided evidence on the potential of EV proteome contents as biomarkers for early disease diagnosis, progression, and treatment response, as well as factors that influence their composition. Additionally, we discuss the available databases containing information on EV proteome contents, and finally, we highlight the need for further research to pave the way toward their utilization in clinical settings.

Original languageEnglish
Title of host publicationFunctional proteomics
EditorsRossen Donev
Place of PublicationUnited Kingdom
PublisherELSEVIER ACADEMIC PRESS INC
Chapter4
Pages101-133
Number of pages33
ISBN (Electronic)9780443193422
DOIs
Publication statusPublished - Jan 2024

Publication series

NameAdvances in Protein Chemistry and Structural Biology
Volume138
ISSN (Print)1876-1623
ISSN (Electronic)1876-1631

Keywords

  • Diagnostic
  • Exosome
  • Extracellular vesicles
  • Proteomics
  • Theranostic
  • Therapeutic

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