TY - JOUR
T1 - Psychosocial factors associated with perceived cognitive functioning in prostate cancer survivors
T2 - an exploratory cross-sectional analysis
AU - Pembroke, Lorna
AU - Sherman, Kerry A.
AU - Dhillon, Haryana M.
AU - Francis, Heather
AU - Gillatt, David
AU - Gurney, Howard
N1 - Copyright the Author(s) 2025. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
PY - 2025/8
Y1 - 2025/8
N2 - PurposeAs more individuals survive prostate cancer, addressing survivorship concerns like cancer-related cognitive impairment (CRCI) becomes increasingly important. Identifying modifiable psychosocial factors related to CRCI is critical in devising targeted non-pharmacological interventions. We aimed to investigate the psychosocial factors associated with perceived cognitive functioning in prostate cancer survivors (PCS).MethodsAdult PCS, either undergoing hormone therapy or on 'watchful waiting'/ 'active surveillance', were recruited for a cross-sectional survey. Perceived cognitive functioning was measured using the Perceived Cognitive Impairments subscale (PCI20) from the Functional Assessment of Cancer Therapy- Cognitive Function questionnaire. Pearson's correlations and ANOVAs explored the association between PCI20 and psychosocial factors including psychological distress, interpersonal functioning, functional well-being, self-compassion and intellectual engagement. Significant variables were included as predictors in a hierarchical regression, examining the relationship with PCI20 and related psychosocial factors while controlling for demographic, biomedical and lifestyle factors.ResultsOf the 96 respondents, one-third reported low cognitive function. Better perceived cognitive functioning was associated with better physical well-being and functional well-being and lower depression levels. In a regression analysis with depression, physical and functional well-being as predictors, only functional well-being was a significant predictor of perceived cognitive functioning after controlling for cancer treatment and levels of physical activity.ConclusionPerceived cognitive functioning was associated with self-reported quality of life and the ability to participate in day-to-day activities including work and enjoyment. The use of a biopsychosocial approach in identifying modifiable avenues for therapeutic interventions addressing CRCI may be beneficial.
AB - PurposeAs more individuals survive prostate cancer, addressing survivorship concerns like cancer-related cognitive impairment (CRCI) becomes increasingly important. Identifying modifiable psychosocial factors related to CRCI is critical in devising targeted non-pharmacological interventions. We aimed to investigate the psychosocial factors associated with perceived cognitive functioning in prostate cancer survivors (PCS).MethodsAdult PCS, either undergoing hormone therapy or on 'watchful waiting'/ 'active surveillance', were recruited for a cross-sectional survey. Perceived cognitive functioning was measured using the Perceived Cognitive Impairments subscale (PCI20) from the Functional Assessment of Cancer Therapy- Cognitive Function questionnaire. Pearson's correlations and ANOVAs explored the association between PCI20 and psychosocial factors including psychological distress, interpersonal functioning, functional well-being, self-compassion and intellectual engagement. Significant variables were included as predictors in a hierarchical regression, examining the relationship with PCI20 and related psychosocial factors while controlling for demographic, biomedical and lifestyle factors.ResultsOf the 96 respondents, one-third reported low cognitive function. Better perceived cognitive functioning was associated with better physical well-being and functional well-being and lower depression levels. In a regression analysis with depression, physical and functional well-being as predictors, only functional well-being was a significant predictor of perceived cognitive functioning after controlling for cancer treatment and levels of physical activity.ConclusionPerceived cognitive functioning was associated with self-reported quality of life and the ability to participate in day-to-day activities including work and enjoyment. The use of a biopsychosocial approach in identifying modifiable avenues for therapeutic interventions addressing CRCI may be beneficial.
KW - cognition
KW - hormone therapy
KW - prostate cancer
KW - psychosocial factors
KW - quality of life
UR - http://www.scopus.com/inward/record.url?scp=105012431832&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=mq-pure-production&SrcAuth=WosAPI&KeyUT=WOS:001543133300002&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1007/s00520-025-09771-5
DO - 10.1007/s00520-025-09771-5
M3 - Article
C2 - 40753137
AN - SCOPUS:105012431832
SN - 0941-4355
VL - 33
SP - 1
EP - 12
JO - Supportive Care in Cancer
JF - Supportive Care in Cancer
IS - 8
M1 - 744
ER -