Pulse oximeter saturation targeting and oximeter changes in the benefits of oxygen saturation targeting (BOOST)-II Australia and BOOST-II UK oxygen trials

Benjamin J. Stenson*, Mark Donoghoe, Peter Brocklehurst, Peter G. Davis, Edmund Juszczak, Ian C. Marschner, John Simes, William O. Tarnow-Mordi

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)

    Abstract

    Infants in the Australian and UK Benefits of Oxygen Saturation Targeting-II trials treated using revised oximeters spent more time within their planned pulse oximeter saturation target ranges than infants treated using the original oximeters (P <.001). This may explain the larger mortality difference seen with revised oximeters. If so, average treatment effects from the Neonatal Oxygen Prospective Meta-analysis trials may be underestimates.

    Original languageEnglish
    Pages (from-to)301-304.e2
    Number of pages6
    JournalJournal of Pediatrics
    Volume204
    DOIs
    Publication statusPublished - Jan 2019

    Keywords

    • blindness/epidemiology
    • blindness/etiology
    • cerebral palsy/epidemiology
    • enterocolitis, necrotizing/epidemiology
    • enterocolitis, necrotizing/etiology
    • humans
    • incidence
    • infant
    • infant mortality
    • infant, extremely premature
    • infant, newborn
    • oximetry
    • oxygen/administration & dosage
    • oxygen/adverse effects
    • oxygen/blood
    • trial

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