Pulse oximeter saturation targeting and oximeter changes in the benefits of oxygen saturation targeting (BOOST)-II Australia and BOOST-II UK oxygen trials

Benjamin J. Stenson; Mark Donoghoe; Peter Brocklehurst; Peter G. Davis; Edmund Juszczak; Ian C. Marschner; John Simes; William O. Tarnow-Mordi

doi:10.1016/j.jpeds.2018.08.033

Pulse oximeter saturation targeting and oximeter changes in the benefits of oxygen saturation targeting (BOOST)-II Australia and BOOST-II UK oxygen trials

Benjamin J. Stenson^*, Mark Donoghoe, Peter Brocklehurst, Peter G. Davis, Edmund Juszczak, Ian C. Marschner, John Simes, William O. Tarnow-Mordi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Infants in the Australian and UK Benefits of Oxygen Saturation Targeting-II trials treated using revised oximeters spent more time within their planned pulse oximeter saturation target ranges than infants treated using the original oximeters (P <.001). This may explain the larger mortality difference seen with revised oximeters. If so, average treatment effects from the Neonatal Oxygen Prospective Meta-analysis trials may be underestimates.

Original language	English
Pages (from-to)	301-304.e2
Number of pages	6
Journal	Journal of Pediatrics
Volume	204
DOIs	https://doi.org/10.1016/j.jpeds.2018.08.033
Publication status	Published - Jan 2019

Keywords

blindness/epidemiology
blindness/etiology
cerebral palsy/epidemiology
enterocolitis, necrotizing/epidemiology
enterocolitis, necrotizing/etiology
humans
incidence
infant
infant mortality
infant, extremely premature
infant, newborn
oximetry
oxygen/administration & dosage
oxygen/adverse effects
oxygen/blood
trial

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10.1016/j.jpeds.2018.08.033

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Stenson, B. J., Donoghoe, M., Brocklehurst, P., Davis, P. G., Juszczak, E., Marschner, I. C., Simes, J., & Tarnow-Mordi, W. O. (2019). Pulse oximeter saturation targeting and oximeter changes in the benefits of oxygen saturation targeting (BOOST)-II Australia and BOOST-II UK oxygen trials. Journal of Pediatrics, 204, 301-304.e2. https://doi.org/10.1016/j.jpeds.2018.08.033

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abstract = "Infants in the Australian and UK Benefits of Oxygen Saturation Targeting-II trials treated using revised oximeters spent more time within their planned pulse oximeter saturation target ranges than infants treated using the original oximeters (P <.001). This may explain the larger mortality difference seen with revised oximeters. If so, average treatment effects from the Neonatal Oxygen Prospective Meta-analysis trials may be underestimates.",

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AU - Davis, Peter G.

AU - Juszczak, Edmund

AU - Marschner, Ian C.

AU - Simes, John

AU - Tarnow-Mordi, William O.

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KW - enterocolitis, necrotizing/epidemiology

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KW - humans

KW - incidence

KW - infant

KW - infant mortality

KW - infant, extremely premature

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JO - Journal of Pediatrics

JF - Journal of Pediatrics

ER -

Pulse oximeter saturation targeting and oximeter changes in the benefits of oxygen saturation targeting (BOOST)-II Australia and BOOST-II UK oxygen trials

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Keywords

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