Pulse pressure predicts cardiovascular risk in patients with type 2 diabetes mellitus

John R. Cockcroft*, Ian B. Wilkinson, Marc Evans, Philip McEwan, John R. Peters, Steve Davies, Maurice F. Scanlon, Craig J. Currie

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)


Background: Pulse pressure (PP), a marker of arterial stiffness, is a better predictor of coronary heart disease (CHD) risk than systolic blood pressure (SBP) or diastolic blood pressure (DBP) in older adults. Whether this is also true in subjects with type 2 diabetes, who are at increased risk for cardiovascular disease, is unknown. Methods: Data on 2911 type 2 diabetic subjects relating to blood pressure (BP), other risk factors, and cardiovascular events were abstracted from The Cardiff Diabetes Database. Logistic regression was used to assess the relationship among BP components and the risk of CHD, cerebrovascular (CVD), and peripheral vascular (PVD) events after correction for age, gender, cholesterol, and smoking status. Results: In the 4-year follow-up period there were 574 CHD, 168 CVD, and 157 PVD events. Both PP and SBP, but not DBP, were positively associated with the risk of all event types. However, PP emerged as the best predictor of CHD events, and SBP as the best predictor of CVD and PVD events. Total and HDL-cholesterol were the most important variables associated with PP after age. Conclusions: In summary, PP is a better predictor of CHD events than SBP in persons with type 2 diabetes, but the converse is true for CVD and PVD.

Original languageEnglish
Pages (from-to)1463-1467
Number of pages5
JournalAmerican Journal of Hypertension
Issue number11
Publication statusPublished - Nov 2005


  • Cardiovascular risk
  • Diabetes
  • Pulse pressure


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