TY - JOUR
T1 - Pupil response biomarkers for early detection and monitoring of Alzheimer's disease
AU - Frost, Shaun
AU - Kanagasingam, Yogesan
AU - Sohrabi, Hamid
AU - Bourgeat, Pierrick
AU - Villemagne, Victor
AU - Rowe, Christopher C.
AU - Macaulay, S. Lance
AU - Szoeke, Cassandra
AU - Ellis, Kathryn A.
AU - Ames, David
AU - Masters, Colin L.
AU - Rainey-Smith, Stephanie
AU - Martins, Ralph N.
AU - The AIBL Research Group
PY - 2013/11
Y1 - 2013/11
N2 - A screening process that could provide early and accurate diagnosis or prognosis for Alzheimer's disease (AD) would enable earlier intervention, and enable current and future treatments to be more effective. Ocular pathology and changes to vision and ocular function are being investigated for early detection and monitoring of AD. To explore the relationship between pupil flash response (PFR) parameters, AD and brain amyloid plaque burden. Nineteen AD and seventy healthy control (HC) participants were recruited from the Australian Imaging, Biomarkers and Lifestyle (AIBL) Flagship Study of Ageing. The potential correlations between PFR parameters and 1) AD and 2) brain amyloid plaque burden in the HC group (as a pre-clinical feature of AD), were investigated in this study. Our results demonstrate statistically significant relationships between PFR parameters, neocortical plaque burden and AD. A logistical model combining PFR parameters provided AD-classification performance with sensitivity 84.1%, specificity 78.3% and area under the curve 89.6%. Furthermore, some of the AD specific PFR parameters were also associated with neocortical plaque burden in pre-clinical AD. These PFR changes show potential as an adjunct for noninvasive, cost-effective screening for pre-clinical AD.
AB - A screening process that could provide early and accurate diagnosis or prognosis for Alzheimer's disease (AD) would enable earlier intervention, and enable current and future treatments to be more effective. Ocular pathology and changes to vision and ocular function are being investigated for early detection and monitoring of AD. To explore the relationship between pupil flash response (PFR) parameters, AD and brain amyloid plaque burden. Nineteen AD and seventy healthy control (HC) participants were recruited from the Australian Imaging, Biomarkers and Lifestyle (AIBL) Flagship Study of Ageing. The potential correlations between PFR parameters and 1) AD and 2) brain amyloid plaque burden in the HC group (as a pre-clinical feature of AD), were investigated in this study. Our results demonstrate statistically significant relationships between PFR parameters, neocortical plaque burden and AD. A logistical model combining PFR parameters provided AD-classification performance with sensitivity 84.1%, specificity 78.3% and area under the curve 89.6%. Furthermore, some of the AD specific PFR parameters were also associated with neocortical plaque burden in pre-clinical AD. These PFR changes show potential as an adjunct for noninvasive, cost-effective screening for pre-clinical AD.
KW - Alzheimer's
KW - aging
KW - diagnosis
KW - pupil
KW - screening
KW - vision
UR - http://www.scopus.com/inward/record.url?scp=84902238121&partnerID=8YFLogxK
M3 - Article
C2 - 24117119
AN - SCOPUS:84902238121
SN - 1567-2050
VL - 10
SP - 931
EP - 939
JO - Current Alzheimer Research
JF - Current Alzheimer Research
IS - 9
ER -