Quality of life in functional dyspepsia: responsiveness of the nepean dyspepsia index and development of a new 10-item short form

N J Talley, Marleen Verlinden, Mike Jones

Research output: Contribution to journalArticlepeer-review

82 Citations (Scopus)

Abstract

BACKGROUND: The Nepean Dyspepsia Index is a reliable and valid measure of quality of life in functional dyspepsia, but responsiveness has been little studied. The Nepean Dyspepsia Index originally contained 42 items designed to measure impairment of a subject's ability to engage in relevant aspects of their life because of dyspepsia, and their enjoyment of these aspects; in addition, the individual importance of areas was assessed. It was subsequently shortened to 25 items, yielding five sub-scales.

AIM: To test the Nepean Dyspepsia Index's responsiveness and develop a responsive, very short form.

METHODS: A randomized, double-blind controlled trial was performed in 589 patients with documented functional dyspepsia. Symptoms and quality of life were measured at baseline, 2 and 4 weeks. Responsiveness of the Nepean Dyspepsia Index quality-of-life section was evaluated by correlation with symptom scores and calculation of standardized changes in scores. Two items from each sub-scale which best represented the area of life (by factor loadings) were selected to create the 10-item short form (SF; short form-Nepean Dyspepsia Index). Internal consistency was assessed by Cronbach's alpha and responsiveness was assessed as above.

RESULTS: The Nepean Dyspepsia Index quality-of-life scales demonstrated excellent responsiveness to change in both the active and placebo arms (standardized response means all > 1.0). The Nepean Dyspepsia Index accounted for only 8% of the variance in percentage change in symptoms (by visual analogue scales), indicating that it was evaluating areas of life not covered by symptoms. The 10-item short form had adequate internal consistency (all scales > or = 0.70) and all strongly (and significantly) correlated with the long form sub-scales; it was also highly responsive.

CONCLUSION: The Nepean Dyspepsia Index is a responsive disease-specific quality-of-life measure; the 10-item short form can be applied in clinical trials of functional dyspepsia.

Original languageEnglish
Pages (from-to)207-216
Number of pages10
JournalAlimentary Pharmacology and Therapeutics
Volume15
Issue number2
DOIs
Publication statusPublished - Feb 2001
Externally publishedYes

Keywords

  • Dyspepsia
  • Female
  • Humans
  • Male
  • Outcome Assessment (Health Care)
  • Quality of Life
  • Surveys and Questionnaires
  • Clinical Trial
  • Journal Article
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

Fingerprint

Dive into the research topics of 'Quality of life in functional dyspepsia: responsiveness of the nepean dyspepsia index and development of a new 10-item short form'. Together they form a unique fingerprint.

Cite this