Quality of life in obsessive-compulsive disorder

An evaluation of impairment and a preliminary analysis of the ameliorating effects of treatment

Melissa M. Norberg, John E. Calamari, Robyn J. Cohen, Bradley C. Riemann

Research output: Contribution to journalArticle

70 Citations (Scopus)


Despite the substantial impairments in life functioning associated with obsessive-compulsive disorder (OCD), treatment outcome evaluations have focused almost exclusively on symptom reduction, a focus that may be too narrow to determine whether clinically significant change has occurred. Quality of life (QOL) impairment was evaluated in a clinical OCD sample (N = 188) using a multidimensional life satisfaction measure. Refaionships between treatment response and QOL change also were evaluated with a subsample of participants (n = 120). Congruent with previous studies of OCD, substantial pretreatment QOL impairment was found across all life domains. Distinct treatment change subgroups were identified: a group reporting strong symptom reduction and very good QOL gains, a second group with significant symptom reduction but less robust QOL improvements, and a third group with limited symptom gains and QOL decreases. Implications for understanding OCD-related impairment and the clinical significance of treatment outcomes are discussed.

Original languageEnglish
Pages (from-to)248-259
Number of pages12
JournalDepression and Anxiety
Issue number3
Publication statusPublished - 2008
Externally publishedYes

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