Quantifying realized inbreeding in wild and captive animal populations

U. Knief*, G. Hemmrich-Stanisak, M. Wittig, A. Franke, S. C. Griffith, B. Kempenaers, W. Forstmeier

*Corresponding author for this work

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Most molecular measures of inbreeding do not measure inbreeding at the scale that is most relevant for understanding inbreeding depression - namely the proportion of the genome that is identical-by-descent (IBD). The inbreeding coefficient F Ped obtained from pedigrees is a valuable estimator of IBD, but pedigrees are not always available, and cannot capture inbreeding loops that reach back in time further than the pedigree. We here propose a molecular approach to quantify the realized proportion of the genome that is IBD (propIBD), and we apply this method to a wild and a captive population of zebra finches (Taeniopygia guttata). In each of 948 wild and 1057 captive individuals we analyzed available single-nucleotide polymorphism (SNP) data (260 SNPs) spread over four different genomic regions in each population. This allowed us to determine whether any of these four regions was completely homozygous within an individual, which indicates IBD with high confidence. In the highly nomadic wild population, we did not find a single case of IBD, implying that inbreeding must be extremely rare (propIBD=0-0.00094, 95% CI). In the captive population, a five-generation pedigree strongly underestimated the average amount of realized inbreeding (F Ped =0.013<propIBD=0.064), as expected given that pedigree founders were already related. We suggest that this SNP-based technique is generally useful for quantifying inbreeding at the individual or population level, and we show analytically that it can capture inbreeding loops that reach back up to a few hundred generations.

Original languageEnglish
Pages (from-to)397-403
Number of pages7
JournalHeredity
Volume114
Issue number4
DOIs
Publication statusPublished - 12 Apr 2015

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