Quantitative blood flow velocity imaging using laser speckle flowmetry

Annemarie Nadort, Koen Kalkman, Ton G. Van Leeuwen, Dirk J. Faber*

*Corresponding author for this work

Research output: Contribution to journalArticle

29 Citations (Scopus)
14 Downloads (Pure)

Abstract

Laser speckle flowmetry suffers from a debated quantification of the inverse relation between decorrelation time (τc) and blood flow velocity (V), i.e. 1/τc = αV. Using a modified microcirculation imager (integrated sidestream dark field - laser speckle contrast imaging [SDF-LSCI]), we experimentally investigate on the influence of the optical properties of scatterers on α in vitro and in vivo. We found a good agreement to theoretical predictions within certain limits for scatterer size and multiple scattering. We present a practical model-based scaling factor to correct for multiple scattering in microcirculatory vessels. Our results show that SDF-LSCI offers a quantitative measure of flow velocity in addition to vessel morphology, enabling the quantification of the clinically relevant blood flow, velocity and tissue perfusion.

Original languageEnglish
Article number25258
Pages (from-to)1-10
Number of pages10
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - 29 Apr 2016

Bibliographical note

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