TY - JOUR
T1 - Quantitative profiling of glycans and glycopeptides
T2 - an informatics’ perspective
AU - Walsh, Ian
AU - Zhao, Sophie
AU - Campbell, Matthew
AU - Taron, Christopher H.
AU - Rudd, Pauline M.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Experimental techniques to identify and quantify glycan structures in a given sample are continuously improving. However, as they advance data analysis and annotation seems to become more complex. To address this issue, much progress has been made in developing software for interpretation of quantitative glycan profiles. Here, we focus on these informatics tools for high/ultra performance liquid chromatography (H/UPLC), mass spectrometry (MS), tandem mass spectrometry (MSn) and combinations thereof. Software for biomarker discovery, pathway, genomic and disease analysis and a final note on some future prospects for glycoinformatics are also mentioned.
AB - Experimental techniques to identify and quantify glycan structures in a given sample are continuously improving. However, as they advance data analysis and annotation seems to become more complex. To address this issue, much progress has been made in developing software for interpretation of quantitative glycan profiles. Here, we focus on these informatics tools for high/ultra performance liquid chromatography (H/UPLC), mass spectrometry (MS), tandem mass spectrometry (MSn) and combinations thereof. Software for biomarker discovery, pathway, genomic and disease analysis and a final note on some future prospects for glycoinformatics are also mentioned.
UR - http://www.scopus.com/inward/record.url?scp=84981294946&partnerID=8YFLogxK
U2 - 10.1016/j.sbi.2016.07.022
DO - 10.1016/j.sbi.2016.07.022
M3 - Review article
C2 - 27522273
AN - SCOPUS:84981294946
SN - 0959-440X
VL - 40
SP - 70
EP - 80
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
ER -