Quantitative profiling of glycans and glycopeptides: an informatics’ perspective

Ian Walsh, Sophie Zhao, Matthew Campbell, Christopher H. Taron, Pauline M. Rudd

Research output: Contribution to journalReview articlepeer-review

24 Citations (Scopus)

Abstract

Experimental techniques to identify and quantify glycan structures in a given sample are continuously improving. However, as they advance data analysis and annotation seems to become more complex. To address this issue, much progress has been made in developing software for interpretation of quantitative glycan profiles. Here, we focus on these informatics tools for high/ultra performance liquid chromatography (H/UPLC), mass spectrometry (MS), tandem mass spectrometry (MSn) and combinations thereof. Software for biomarker discovery, pathway, genomic and disease analysis and a final note on some future prospects for glycoinformatics are also mentioned.

Original languageEnglish
Pages (from-to)70-80
Number of pages11
JournalCurrent Opinion in Structural Biology
Volume40
DOIs
Publication statusPublished - 1 Oct 2016

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