Quantitative proton magnetic resonance spectroscopy in presence of sidebands

Mahir Sinan Ozdemir*, Yves De Deene, Eric Achten, Yves D'Asseler, Ignace Lemahieu

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

2 Citations (Scopus)

Abstract

We perform Proton Magnetic Resonance Spectroscopy (MRS) without water suppression in contrast to traditional water-suppressed MRS. The preserved water signal can be used as a reference for the absolute quantification of metabolites, reducing the total measurement time. However, the non-water-suppressed spectra can be contaminated by gradient-induced frequency modulations resulting in sidebands in the spectrum. Sidebands may obscure the metabolite resonances of interest, thereby rendering the spectral analysis and quantification problematic. To this end, we present a correction technique to remove sidebands. The proposed method utilizes the phase of an external reference of single resonance to observe the time-varying the static field fluctuation induced by gradient-vibrations then deconvolves this phase contamination from the desired signal obtained under the same experimental conditions. The method is evaluated by phantom and in vivo measurements.

Original languageEnglish
Title of host publication2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings
Place of PublicationPiscataway, NJ
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Pages1008-1011
Number of pages4
ISBN (Print)1424406722, 9781424406722
DOIs
Publication statusPublished - 2007
Externally publishedYes
Event2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro; ISBI'07 - Arlington, VA, United States
Duration: 12 Apr 200715 Apr 2007

Other

Other2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro; ISBI'07
CountryUnited States
CityArlington, VA
Period12/04/0715/04/07

Keywords

  • Absolute quantification
  • Magnetic resonance spectroscopy
  • Sidebands
  • Water suppression

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