Quantitative proton magnetic resonance spectroscopy in presence of sidebands

Mahir Sinan Ozdemir; Yves De Deene; Eric Achten; Yves D'Asseler; Ignace Lemahieu

doi:10.1109/ISBI.2007.357025

Quantitative proton magnetic resonance spectroscopy in presence of sidebands

Mahir Sinan Ozdemir^*, Yves De Deene, Eric Achten, Yves D'Asseler, Ignace Lemahieu

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

2 Citations (Scopus)

Abstract

We perform Proton Magnetic Resonance Spectroscopy (MRS) without water suppression in contrast to traditional water-suppressed MRS. The preserved water signal can be used as a reference for the absolute quantification of metabolites, reducing the total measurement time. However, the non-water-suppressed spectra can be contaminated by gradient-induced frequency modulations resulting in sidebands in the spectrum. Sidebands may obscure the metabolite resonances of interest, thereby rendering the spectral analysis and quantification problematic. To this end, we present a correction technique to remove sidebands. The proposed method utilizes the phase of an external reference of single resonance to observe the time-varying the static field fluctuation induced by gradient-vibrations then deconvolves this phase contamination from the desired signal obtained under the same experimental conditions. The method is evaluated by phantom and in vivo measurements.

Original language	English
Title of host publication	2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings
Place of Publication	Piscataway, NJ
Publisher	Institute of Electrical and Electronics Engineers (IEEE)
Pages	1008-1011
Number of pages	4
ISBN (Print)	1424406722, 9781424406722
DOIs	https://doi.org/10.1109/ISBI.2007.357025
Publication status	Published - 2007
Externally published	Yes
Event	2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro; ISBI'07 - Arlington, VA, United States Duration: 12 Apr 2007 → 15 Apr 2007

Other

Other	2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro; ISBI'07
Country/Territory	United States
City	Arlington, VA
Period	12/04/07 → 15/04/07

Keywords

Absolute quantification
Magnetic resonance spectroscopy
Sidebands
Water suppression

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10.1109/ISBI.2007.357025

Cite this

Ozdemir, M. S., De Deene, Y., Achten, E., D'Asseler, Y., & Lemahieu, I. (2007). Quantitative proton magnetic resonance spectroscopy in presence of sidebands. In 2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings (pp. 1008-1011). Article 4193459 Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/ISBI.2007.357025

@inproceedings{2a04822549a34f678c7bd80f28ea735c,

title = "Quantitative proton magnetic resonance spectroscopy in presence of sidebands",

abstract = "We perform Proton Magnetic Resonance Spectroscopy (MRS) without water suppression in contrast to traditional water-suppressed MRS. The preserved water signal can be used as a reference for the absolute quantification of metabolites, reducing the total measurement time. However, the non-water-suppressed spectra can be contaminated by gradient-induced frequency modulations resulting in sidebands in the spectrum. Sidebands may obscure the metabolite resonances of interest, thereby rendering the spectral analysis and quantification problematic. To this end, we present a correction technique to remove sidebands. The proposed method utilizes the phase of an external reference of single resonance to observe the time-varying the static field fluctuation induced by gradient-vibrations then deconvolves this phase contamination from the desired signal obtained under the same experimental conditions. The method is evaluated by phantom and in vivo measurements.",

keywords = "Absolute quantification, Magnetic resonance spectroscopy, Sidebands, Water suppression",

author = "Ozdemir, \{Mahir Sinan\} and \{De Deene\}, Yves and Eric Achten and Yves D'Asseler and Ignace Lemahieu",

year = "2007",

doi = "10.1109/ISBI.2007.357025",

language = "English",

isbn = "1424406722",

pages = "1008--1011",

booktitle = "2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings",

publisher = "Institute of Electrical and Electronics Engineers (IEEE)",

address = "United States",

note = "2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro; ISBI'07 ; Conference date: 12-04-2007 Through 15-04-2007",

}

Ozdemir, MS, De Deene, Y, Achten, E, D'Asseler, Y & Lemahieu, I 2007, Quantitative proton magnetic resonance spectroscopy in presence of sidebands. in 2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings., 4193459, Institute of Electrical and Electronics Engineers (IEEE), Piscataway, NJ, pp. 1008-1011, 2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro; ISBI'07, Arlington, VA, United States, 12/04/07. https://doi.org/10.1109/ISBI.2007.357025

Quantitative proton magnetic resonance spectroscopy in presence of sidebands. / Ozdemir, Mahir Sinan; De Deene, Yves; Achten, Eric et al.
2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings. Piscataway, NJ: Institute of Electrical and Electronics Engineers (IEEE), 2007. p. 1008-1011 4193459.

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

TY - GEN

T1 - Quantitative proton magnetic resonance spectroscopy in presence of sidebands

AU - Ozdemir, Mahir Sinan

AU - De Deene, Yves

AU - Achten, Eric

AU - D'Asseler, Yves

AU - Lemahieu, Ignace

PY - 2007

Y1 - 2007

N2 - We perform Proton Magnetic Resonance Spectroscopy (MRS) without water suppression in contrast to traditional water-suppressed MRS. The preserved water signal can be used as a reference for the absolute quantification of metabolites, reducing the total measurement time. However, the non-water-suppressed spectra can be contaminated by gradient-induced frequency modulations resulting in sidebands in the spectrum. Sidebands may obscure the metabolite resonances of interest, thereby rendering the spectral analysis and quantification problematic. To this end, we present a correction technique to remove sidebands. The proposed method utilizes the phase of an external reference of single resonance to observe the time-varying the static field fluctuation induced by gradient-vibrations then deconvolves this phase contamination from the desired signal obtained under the same experimental conditions. The method is evaluated by phantom and in vivo measurements.

AB - We perform Proton Magnetic Resonance Spectroscopy (MRS) without water suppression in contrast to traditional water-suppressed MRS. The preserved water signal can be used as a reference for the absolute quantification of metabolites, reducing the total measurement time. However, the non-water-suppressed spectra can be contaminated by gradient-induced frequency modulations resulting in sidebands in the spectrum. Sidebands may obscure the metabolite resonances of interest, thereby rendering the spectral analysis and quantification problematic. To this end, we present a correction technique to remove sidebands. The proposed method utilizes the phase of an external reference of single resonance to observe the time-varying the static field fluctuation induced by gradient-vibrations then deconvolves this phase contamination from the desired signal obtained under the same experimental conditions. The method is evaluated by phantom and in vivo measurements.

KW - Absolute quantification

KW - Magnetic resonance spectroscopy

KW - Sidebands

KW - Water suppression

UR - https://www.scopus.com/pages/publications/36348958414

U2 - 10.1109/ISBI.2007.357025

DO - 10.1109/ISBI.2007.357025

M3 - Conference proceeding contribution

AN - SCOPUS:36348958414

SN - 1424406722

SN - 9781424406722

SP - 1008

EP - 1011

BT - 2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings

PB - Institute of Electrical and Electronics Engineers (IEEE)

CY - Piscataway, NJ

T2 - 2007 4th IEEE International Symposium on Biomedical Imaging: From Nano to Macro; ISBI'07

Y2 - 12 April 2007 through 15 April 2007

ER -

Quantitative proton magnetic resonance spectroscopy in presence of sidebands

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