Quantitative SPECT reconstruction using CT-derived corrections

Kathy Willowson; Dale L. Bailey; Clive Baldock

doi:10.1088/0031-9155/53/12/002

Quantitative SPECT reconstruction using CT-derived corrections

Kathy Willowson, Dale L. Bailey, Clive Baldock

Research output: Contribution to journal › Article › peer-review

114 Citations (Scopus)

Abstract

A method for achieving quantitative single-photon emission computed tomography (SPECT) based upon corrections derived from x-ray computed tomography (CT) data is presented. A CT-derived attenuation map is used to perform transmission-dependent scatter correction (TDSC) in conjunction with non-uniform attenuation correction. The original CT data are also utilized to correct for partial volume effects in small volumes of interest. The accuracy of the quantitative technique has been evaluated with phantom experiments and clinical lung ventilation/perfusion SPECT/CT studies. A comparison of calculated values with the known total activities and concentrations in a mixed-material cylindrical phantom, and in liver and cardiac inserts within an anthropomorphic torso phantom, produced accurate results. The total activity in corrected ventilation-subtracted perfusion images was compared to the calibrated injected dose of [99mTc]-MAA (macro-aggregated albumin). The average difference over 12 studies between the known and calculated activities was found to be -1%, with a range of ±7%.

Original language	English
Pages (from-to)	3099-3112
Number of pages	14
Journal	Physics in Medicine and Biology
Volume	53
Issue number	12
DOIs	https://doi.org/10.1088/0031-9155/53/12/002
Publication status	Published - 2008
Externally published	Yes

Access to Document

10.1088/0031-9155/53/12/002

Cite this

@article{e705c3ca307a49e583d3059174759448,

title = "Quantitative SPECT reconstruction using CT-derived corrections",

abstract = "A method for achieving quantitative single-photon emission computed tomography (SPECT) based upon corrections derived from x-ray computed tomography (CT) data is presented. A CT-derived attenuation map is used to perform transmission-dependent scatter correction (TDSC) in conjunction with non-uniform attenuation correction. The original CT data are also utilized to correct for partial volume effects in small volumes of interest. The accuracy of the quantitative technique has been evaluated with phantom experiments and clinical lung ventilation/perfusion SPECT/CT studies. A comparison of calculated values with the known total activities and concentrations in a mixed-material cylindrical phantom, and in liver and cardiac inserts within an anthropomorphic torso phantom, produced accurate results. The total activity in corrected ventilation-subtracted perfusion images was compared to the calibrated injected dose of [99mTc]-MAA (macro-aggregated albumin). The average difference over 12 studies between the known and calculated activities was found to be -1%, with a range of ±7%.",

author = "Kathy Willowson and Bailey, {Dale L.} and Clive Baldock",

year = "2008",

doi = "10.1088/0031-9155/53/12/002",

language = "English",

volume = "53",

pages = "3099--3112",

journal = "Physics in Medicine and Biology",

issn = "0031-9155",

publisher = "Institute of Physics",

number = "12",

}

TY - JOUR

T1 - Quantitative SPECT reconstruction using CT-derived corrections

AU - Willowson, Kathy

AU - Bailey, Dale L.

AU - Baldock, Clive

PY - 2008

Y1 - 2008

N2 - A method for achieving quantitative single-photon emission computed tomography (SPECT) based upon corrections derived from x-ray computed tomography (CT) data is presented. A CT-derived attenuation map is used to perform transmission-dependent scatter correction (TDSC) in conjunction with non-uniform attenuation correction. The original CT data are also utilized to correct for partial volume effects in small volumes of interest. The accuracy of the quantitative technique has been evaluated with phantom experiments and clinical lung ventilation/perfusion SPECT/CT studies. A comparison of calculated values with the known total activities and concentrations in a mixed-material cylindrical phantom, and in liver and cardiac inserts within an anthropomorphic torso phantom, produced accurate results. The total activity in corrected ventilation-subtracted perfusion images was compared to the calibrated injected dose of [99mTc]-MAA (macro-aggregated albumin). The average difference over 12 studies between the known and calculated activities was found to be -1%, with a range of ±7%.

AB - A method for achieving quantitative single-photon emission computed tomography (SPECT) based upon corrections derived from x-ray computed tomography (CT) data is presented. A CT-derived attenuation map is used to perform transmission-dependent scatter correction (TDSC) in conjunction with non-uniform attenuation correction. The original CT data are also utilized to correct for partial volume effects in small volumes of interest. The accuracy of the quantitative technique has been evaluated with phantom experiments and clinical lung ventilation/perfusion SPECT/CT studies. A comparison of calculated values with the known total activities and concentrations in a mixed-material cylindrical phantom, and in liver and cardiac inserts within an anthropomorphic torso phantom, produced accurate results. The total activity in corrected ventilation-subtracted perfusion images was compared to the calibrated injected dose of [99mTc]-MAA (macro-aggregated albumin). The average difference over 12 studies between the known and calculated activities was found to be -1%, with a range of ±7%.

U2 - 10.1088/0031-9155/53/12/002

DO - 10.1088/0031-9155/53/12/002

M3 - Article

C2 - 18495976

SN - 0031-9155

VL - 53

SP - 3099

EP - 3112

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

IS - 12

ER -

Quantitative SPECT reconstruction using CT-derived corrections

Abstract

Access to Document

Fingerprint

Cite this