Quercetin and the mitochondria: a mechanistic view

Marcos Roberto de Oliveira*, Seyed Mohammad Nabavi, Nady Braidy, William N. Setzer, Touqeer Ahmed, Seyed Fazel Nabavi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

125 Citations (Scopus)

Abstract

Quercetin is an important flavonoid that is ubiquitously present in the diet in a variety of fruits and vegetables. It has been traditionally viewed as a potent antioxidant and anti-inflammatory molecule. However, recent studies have suggested that quercetin may exert its beneficial effects independent of its free radical-scavenging properties. Attention has been placed on the effect of quercetin on an array of mitochondrial processes. Quercetin is now recognized as a phytochemical that can modulate pathways associated with mitochondrial biogenesis, mitochondrial membrane potential, oxidative respiration and ATP anabolism, intra-mitochondrial redox status, and subsequently, mitochondria-induced apoptosis. The present review evaluates recent evidence on the ability of quercetin to interact with the abovementioned pathways, and critically analyses how, such interactions can exert protection against mitochondrial damage in response to toxicity induced by several exogenously and endogenously-produced cellular stressors, and oxidative stress in particular.

Original languageEnglish
Pages (from-to)532-549
Number of pages18
JournalBiotechnology Advances
Volume34
Issue number5
DOIs
Publication statusPublished - 2016
Externally publishedYes

Keywords

  • Antioxidant
  • Apoptosis
  • Mitochondria
  • Mitochondrial biogenesis
  • Quercetin

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