Radiation-induced lipid peroxidation and the fluidity of erythrocyte membrane lipids

Jennifer Guille, John K. Raison, Janusz M. Gebicki*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


The effect of radiation-induced peroxidation nn the fluidity of the phospholipids of the erythrocyte membrane was studied using both erythrocyte ghosts and liposomes formed from the polar lipids of erythrocytes. In liposomes, the oxidation of the phospholipids increased with radiation dose, but there was no change in the fluidity of the lipids as measured by spin-label motion. Under the same conditions of irradiation, no oxidation of phospholipid was detected in erythrocyte ghosts, although changes occurred in the motion of spin labels interealated with the membrane. These changes were attributed to radiation-induced alterations in the membrane proteins. It is concluded that alterations in motion of spin labels, observed with intact membranes after irradiation, are most likely the result of changes in the structure of membrane proteins rather than the lipids.

Original languageEnglish
Pages (from-to)147-152
Number of pages6
JournalFree Radical Biology and Medicine
Issue number2
Publication statusPublished - 1987
Externally publishedYes


  • Erythrocytes
  • Lipid peroxidation
  • Membrane fluidity
  • Membrane lipids
  • Radiation
  • Spin labels


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