Raman and surface-enhanced Raman spectroscopy for renal condition monitoring

Jingting Li, Ming Li, Yong Du, Greggy M. Santos, Chandra Mohan, Wei-Chuan Shih

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review


Non- and minimally-invasive techniques can provide advantages in the monitoring and clinical diagnostics in renal diseases. Although renal biopsy may be useful in establishing diagnosis in several diseases, it is an invasive approach and impractical for longitudinal disease monitoring. To address this unmet need, we have developed two techniques based on Raman spectroscopy. First, we have investigated the potential of diagnosing and staging nephritis by analyzing kidney tissue Raman spectra using multivariate techniques. Secondly, we have developed a urine creatinine sensor based on surface-enhanced Raman spectroscopy with performance near commercial assays which require relatively laborious sample preparation and longer time.
Original languageEnglish
Title of host publicationBiomedical Vibrational Spectroscopy 2016
Subtitle of host publicationAdvances in Research and Industry
EditorsAnita Mahadevan-Jansen, Wolfgang Petrich
Place of PublicationBellingham, WA
Number of pages9
ISBN (Print)9781628419382
Publication statusPublished - 2016
Externally publishedYes
Event2016 SPIE Photonics West: Biomedical Vibrational Spectroscopy 2016: Advances in Research and Industry - San Francisco, United States
Duration: 13 Feb 201614 Feb 2016

Publication series

NameProceedings of SPIE
ISSN (Print)1605-7422
ISSN (Electronic)2410-9045


Conference2016 SPIE Photonics West
Country/TerritoryUnited States
CitySan Francisco


  • principal component analysis
  • linear discriminant analysis
  • creatinine
  • SERS
  • nanoporous gold


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