Randomized controlled trial of a healthy brain ageing cognitive training program: effects on memory, mood, and sleep

Keri Diamond; Loren Mowszowski; Nicole Cockayne; Louisa Norrie; Matthew Paradise; Daniel F. Hermens; Simon J G Lewis; Ian B. Hickie; Sharon L. Naismith

doi:10.3233/978-1-61499-542-5-355

Randomized controlled trial of a healthy brain ageing cognitive training program: effects on memory, mood, and sleep

Keri Diamond, Loren Mowszowski, Nicole Cockayne, Louisa Norrie, Matthew Paradise, Daniel F. Hermens, Simon J G Lewis, Ian B. Hickie, Sharon L. Naismith^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Background: With the rise in the ageing population and absence of a cure for dementia, cost-effective prevention strategies for those 'at risk' of dementia including those with depression and/or mild cognitive impairment are urgently required.

Objective: This study evaluated the efficacy of a multifaceted Healthy Brain Ageing Cognitive Training (HBA-CT) program for older adults 'at risk' of dementia.

Methods: Using a single-blinded design, 64 participants (mean age = 66.5 years, SD = 8.6) were randomized to an immediate treatment (HBA-CT) or treatment-as-usual control arm. The HBA-CT intervention was conducted twice-weekly for seven weeks and comprised group-based psychoeducation about cognitive strategies and modifiable lifestyle factors pertaining to healthy brain ageing, and computerized cognitive training.

Results: In comparison to the treatment-as-usual control arm, the HBA-CT program was associated with improvements in verbal memory (p = 0.03), self-reported memory (p = 0.03), mood (p = 0.01), and sleep (p = 0.01). While the improvements in memory (p = 0.03) and sleep (p = 0.02) remained after controlling for improvements in mood, only a trend in verbal memory improvement was apparent after controlling for sleep.

Conclusion: The HBA-CT program improves cognitive, mood, and sleep functions in older adults 'at risk' of dementia, and therefore offers promise as a secondary prevention strategy.

Original language	English
Title of host publication	Handbook of depression in Alzheimer's disease
Editors	Gwenn S. Smith
Place of Publication	Amsterdam
Publisher	IOS Press
Pages	355-365
Number of pages	11
Volume	4
ISBN (Electronic)	9781614995425
ISBN (Print)	9781614995418
DOIs	https://doi.org/10.3233/978-1-61499-542-5-355
Publication status	Published - 2015
Externally published	Yes

Publication series

Name	Advances in Alzheimer's disease
Volume	4
ISSN (Print)	2210-5727
ISSN (Electronic)	2210-5735

Keywords

depression
memory
mild cognitive impairment
neuropsychology
sleep disorders
Sleep disorders
Mild cognitive impairment
Memory
Depression
Neuropsychology

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10.3233/978-1-61499-542-5-355

Cite this

Diamond, K., Mowszowski, L., Cockayne, N., Norrie, L., Paradise, M., Hermens, D. F., Lewis, S. J. G., Hickie, I. B., & Naismith, S. L. (2015). Randomized controlled trial of a healthy brain ageing cognitive training program: effects on memory, mood, and sleep. In G. S. Smith (Ed.), Handbook of depression in Alzheimer's disease (Vol. 4, pp. 355-365). (Advances in Alzheimer's disease; Vol. 4). IOS Press. https://doi.org/10.3233/978-1-61499-542-5-355

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title = "Randomized controlled trial of a healthy brain ageing cognitive training program: effects on memory, mood, and sleep",

abstract = "Background: With the rise in the ageing population and absence of a cure for dementia, cost-effective prevention strategies for those 'at risk' of dementia including those with depression and/or mild cognitive impairment are urgently required. Objective: This study evaluated the efficacy of a multifaceted Healthy Brain Ageing Cognitive Training (HBA-CT) program for older adults 'at risk' of dementia. Methods: Using a single-blinded design, 64 participants (mean age = 66.5 years, SD = 8.6) were randomized to an immediate treatment (HBA-CT) or treatment-as-usual control arm. The HBA-CT intervention was conducted twice-weekly for seven weeks and comprised group-based psychoeducation about cognitive strategies and modifiable lifestyle factors pertaining to healthy brain ageing, and computerized cognitive training. Results: In comparison to the treatment-as-usual control arm, the HBA-CT program was associated with improvements in verbal memory (p = 0.03), self-reported memory (p = 0.03), mood (p = 0.01), and sleep (p = 0.01). While the improvements in memory (p = 0.03) and sleep (p = 0.02) remained after controlling for improvements in mood, only a trend in verbal memory improvement was apparent after controlling for sleep. Conclusion: The HBA-CT program improves cognitive, mood, and sleep functions in older adults 'at risk' of dementia, and therefore offers promise as a secondary prevention strategy.",

keywords = "depression, memory, mild cognitive impairment, neuropsychology, sleep disorders, Sleep disorders, Mild cognitive impairment, Memory, Depression, Neuropsychology",

author = "Keri Diamond and Loren Mowszowski and Nicole Cockayne and Louisa Norrie and Matthew Paradise and Hermens, {Daniel F.} and Lewis, {Simon J G} and Hickie, {Ian B.} and Naismith, {Sharon L.}",

year = "2015",

doi = "10.3233/978-1-61499-542-5-355",

language = "English",

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Diamond, K, Mowszowski, L, Cockayne, N, Norrie, L, Paradise, M, Hermens, DF, Lewis, SJG, Hickie, IB & Naismith, SL 2015, Randomized controlled trial of a healthy brain ageing cognitive training program: effects on memory, mood, and sleep. in GS Smith (ed.), Handbook of depression in Alzheimer's disease. vol. 4, Advances in Alzheimer's disease, vol. 4, IOS Press, Amsterdam, pp. 355-365. https://doi.org/10.3233/978-1-61499-542-5-355

Randomized controlled trial of a healthy brain ageing cognitive training program: effects on memory, mood, and sleep. / Diamond, Keri; Mowszowski, Loren; Cockayne, Nicole et al.
Handbook of depression in Alzheimer's disease. ed. / Gwenn S. Smith. Vol. 4 Amsterdam: IOS Press, 2015. p. 355-365 (Advances in Alzheimer's disease; Vol. 4).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

TY - CHAP

T1 - Randomized controlled trial of a healthy brain ageing cognitive training program

T2 - effects on memory, mood, and sleep

AU - Diamond, Keri

AU - Mowszowski, Loren

AU - Cockayne, Nicole

AU - Norrie, Louisa

AU - Paradise, Matthew

AU - Hermens, Daniel F.

AU - Lewis, Simon J G

AU - Hickie, Ian B.

AU - Naismith, Sharon L.

PY - 2015

Y1 - 2015

N2 - Background: With the rise in the ageing population and absence of a cure for dementia, cost-effective prevention strategies for those 'at risk' of dementia including those with depression and/or mild cognitive impairment are urgently required. Objective: This study evaluated the efficacy of a multifaceted Healthy Brain Ageing Cognitive Training (HBA-CT) program for older adults 'at risk' of dementia. Methods: Using a single-blinded design, 64 participants (mean age = 66.5 years, SD = 8.6) were randomized to an immediate treatment (HBA-CT) or treatment-as-usual control arm. The HBA-CT intervention was conducted twice-weekly for seven weeks and comprised group-based psychoeducation about cognitive strategies and modifiable lifestyle factors pertaining to healthy brain ageing, and computerized cognitive training. Results: In comparison to the treatment-as-usual control arm, the HBA-CT program was associated with improvements in verbal memory (p = 0.03), self-reported memory (p = 0.03), mood (p = 0.01), and sleep (p = 0.01). While the improvements in memory (p = 0.03) and sleep (p = 0.02) remained after controlling for improvements in mood, only a trend in verbal memory improvement was apparent after controlling for sleep. Conclusion: The HBA-CT program improves cognitive, mood, and sleep functions in older adults 'at risk' of dementia, and therefore offers promise as a secondary prevention strategy.

AB - Background: With the rise in the ageing population and absence of a cure for dementia, cost-effective prevention strategies for those 'at risk' of dementia including those with depression and/or mild cognitive impairment are urgently required. Objective: This study evaluated the efficacy of a multifaceted Healthy Brain Ageing Cognitive Training (HBA-CT) program for older adults 'at risk' of dementia. Methods: Using a single-blinded design, 64 participants (mean age = 66.5 years, SD = 8.6) were randomized to an immediate treatment (HBA-CT) or treatment-as-usual control arm. The HBA-CT intervention was conducted twice-weekly for seven weeks and comprised group-based psychoeducation about cognitive strategies and modifiable lifestyle factors pertaining to healthy brain ageing, and computerized cognitive training. Results: In comparison to the treatment-as-usual control arm, the HBA-CT program was associated with improvements in verbal memory (p = 0.03), self-reported memory (p = 0.03), mood (p = 0.01), and sleep (p = 0.01). While the improvements in memory (p = 0.03) and sleep (p = 0.02) remained after controlling for improvements in mood, only a trend in verbal memory improvement was apparent after controlling for sleep. Conclusion: The HBA-CT program improves cognitive, mood, and sleep functions in older adults 'at risk' of dementia, and therefore offers promise as a secondary prevention strategy.

KW - depression

KW - memory

KW - mild cognitive impairment

KW - neuropsychology

KW - sleep disorders

KW - Sleep disorders

KW - Mild cognitive impairment

KW - Memory

KW - Depression

KW - Neuropsychology

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DO - 10.3233/978-1-61499-542-5-355

M3 - Chapter

AN - SCOPUS:84942899990

SN - 9781614995418

VL - 4

T3 - Advances in Alzheimer's disease

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BT - Handbook of depression in Alzheimer's disease

A2 - Smith, Gwenn S.

PB - IOS Press

CY - Amsterdam

ER -

Diamond K, Mowszowski L, Cockayne N, Norrie L, Paradise M, Hermens DF et al. Randomized controlled trial of a healthy brain ageing cognitive training program: effects on memory, mood, and sleep. In Smith GS, editor, Handbook of depression in Alzheimer's disease. Vol. 4. Amsterdam: IOS Press. 2015. p. 355-365. (Advances in Alzheimer's disease). doi: 10.3233/978-1-61499-542-5-355

Randomized controlled trial of a healthy brain ageing cognitive training program: effects on memory, mood, and sleep

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