Randomized controlled trial of a healthy brain ageing cognitive training program

effects on memory, mood, and sleep

Keri Diamond, Loren Mowszowski, Nicole Cockayne, Louisa Norrie, Matthew Paradise, Daniel F. Hermens, Simon J G Lewis, Ian B. Hickie, Sharon L. Naismith*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Background: With the rise in the ageing population and absence of a cure for dementia, cost-effective prevention strategies for those 'at risk' of dementia including those with depression and/or mild cognitive impairment are urgently required.

Objective: This study evaluated the efficacy of a multifaceted Healthy Brain Ageing Cognitive Training (HBA-CT) program for older adults 'at risk' of dementia.

Methods: Using a single-blinded design, 64 participants (mean age = 66.5 years, SD = 8.6) were randomized to an immediate treatment (HBA-CT) or treatment-as-usual control arm. The HBA-CT intervention was conducted twice-weekly for seven weeks and comprised group-based psychoeducation about cognitive strategies and modifiable lifestyle factors pertaining to healthy brain ageing, and computerized cognitive training.

Results: In comparison to the treatment-as-usual control arm, the HBA-CT program was associated with improvements in verbal memory (p = 0.03), self-reported memory (p = 0.03), mood (p = 0.01), and sleep (p = 0.01). While the improvements in memory (p = 0.03) and sleep (p = 0.02) remained after controlling for improvements in mood, only a trend in verbal memory improvement was apparent after controlling for sleep.

Conclusion: The HBA-CT program improves cognitive, mood, and sleep functions in older adults 'at risk' of dementia, and therefore offers promise as a secondary prevention strategy.

Original languageEnglish
Title of host publicationHandbook of depression in Alzheimer's disease
EditorsGwenn S. Smith
Place of PublicationAmsterdam
PublisherIOS Press
Pages355-365
Number of pages11
Volume4
ISBN (Electronic)9781614995425
ISBN (Print)9781614995418
DOIs
Publication statusPublished - 2015
Externally publishedYes

Publication series

NameAdvances in Alzheimer's disease
Volume4
ISSN (Print)2210-5727
ISSN (Electronic)2210-5735

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Keywords

  • depression
  • memory
  • mild cognitive impairment
  • neuropsychology
  • sleep disorders
  • Sleep disorders
  • Mild cognitive impairment
  • Memory
  • Depression
  • Neuropsychology

Cite this

Diamond, K., Mowszowski, L., Cockayne, N., Norrie, L., Paradise, M., Hermens, D. F., ... Naismith, S. L. (2015). Randomized controlled trial of a healthy brain ageing cognitive training program: effects on memory, mood, and sleep. In G. S. Smith (Ed.), Handbook of depression in Alzheimer's disease (Vol. 4, pp. 355-365). (Advances in Alzheimer's disease; Vol. 4). Amsterdam: IOS Press. https://doi.org/10.3233/978-1-61499-542-5-355