Rapid decline in episodic memory in healthy older adults with high amyloid-β

Yen Ying Lim*, Robert H. Pietrzak, Kathryn A. Ellis, Judith Jaeger, Karra Harrington, Tim Ashwood, Cassandra Szoeke, Ralph N. Martins, Ashley I. Bush, Colin L. Masters, Christopher C. Rowe, Victor L. Villemagne, David Ames, David Darby, Paul Maruff

*Corresponding author for this work

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

High levels of amyloid-β (Aβ) have been associated with greater rates of decline in episodic memory over 18 months in healthy older adults. Serial assessments over shorter time intervals may facilitate earlier detection of Aβ-related memory decline in healthy older adults. In forty-four healthy older adults enrolled in the Australian Imaging, Biomarkers and Lifestyle Rate of Change Sub-Study, we compared rates of change in cognition over six months in healthy older adults with high and low levels of Aβ. High Aβ was associated with greater decline in episodic memory measures over 6 months in healthy older adults.

Original languageEnglish
Pages (from-to)675-679
Number of pages5
JournalJournal of Alzheimer's Disease
Volume33
Issue number3
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • Alzheimer's disease
  • amyloid-β
  • cognitive decline
  • episodic memory
  • neuropsychological assessment

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    Lim, Y. Y., Pietrzak, R. H., Ellis, K. A., Jaeger, J., Harrington, K., Ashwood, T., ... Maruff, P. (2013). Rapid decline in episodic memory in healthy older adults with high amyloid-β. Journal of Alzheimer's Disease, 33(3), 675-679. https://doi.org/10.3233/JAD-2012-121516