Rapid electrochemical ultra-sensitive evaluation and determination of daptomycin based on continuous cyclic voltammetry

Navid Rabiee, Moein Safarkhani, Mohammad Rabiee*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background: In this work, a novel and extra sensitive blood sample determination method for on-line monitoring of Daptomycin is represented.

Materials and Methods: This technique is in accordance with the electro-membrane extraction (EME) and stripping fast Fourier transform continuous cyclic voltammetry (SFFTCCV) coupling. Briefly, the potential waveform had become constantly utilized over a Gold Electrode and the electrode impulse was acquired by taking away the base current and developing the current in the particular potential area of oxidation of sample.

Results: This method was performed by utilizing a DC potential and migration of Daptomycin from the analyte fluid to the layer of 4-methyl-2-pentanol as well as following migration to the acceptor fluid.

Conclusion: A low and valuable detection limit of 3.5 ng ml-1 and quantification limit of 10.2 ng ml-1 are considered as a part of the sensible results of this experiment. Furthermore, efficient linearity in the range of 10.0-600 ng ml-1 was observed.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalCurrent Pharmaceutical Analysis
Volume16
Issue number2
DOIs
Publication statusPublished - 2020
Externally publishedYes

Keywords

  • Continuous cyclic voltammetry
  • Daptomycin
  • Electrochemical
  • Rapid determination
  • Resistance mechanisms
  • Ultra-sensitive

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