Rat serum amyloid P component. Analysis of cDNA sequence and gene expression

S. B. Dowton*, S. D. McGrew

*Corresponding author for this work

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

cDNA clones for rat serum amyloid P component (SAP) were isolated, and the derived amino acid sequence for pre-SAP was determined from the complete nucleotide sequence. Rat SAP is encoded by ~1 kb of mRNA, and the mature SAP protein is predicted to be 208 amino acids long. An increase in hepatic mRNA levels of rat SAP was found after administration of lipopolysaccharide, and SAP mRNA levels in livers of unstimulated male rats were lower than in hepatic RNA from female rats.

Original languageEnglish
Pages (from-to)553-556
Number of pages4
JournalBiochemical Journal
Volume270
Issue number2
Publication statusPublished - 1990
Externally publishedYes

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