Rates of age- and amyloid β-associated cortical atrophy in older adults with superior memory performance

Christa Dang; Nawaf Yassi; Karra D. Harrington; Ying Xia; Yen Ying Lim; David Ames; Simon M. Laws; Martha Hickey; Stephanie Rainey-Smith; Hamid R. Sohrabi; James D. Doecke; Jurgen Fripp; Olivier Salvado; Peter J. Snyder; Michael Weinborn; Victor L. Villemagne; Christopher C. Rowe; Colin L. Masters; Paul Maruff; The AIBL Research Group

doi:10.1016/j.dadm.2019.05.005

Rates of age- and amyloid β-associated cortical atrophy in older adults with superior memory performance

Christa Dang
, Nawaf Yassi
, Karra D. Harrington
, Ying Xia
, Yen Ying Lim
, David Ames
, Simon M. Laws
, Martha Hickey
, Stephanie Rainey-Smith
, Hamid R. Sohrabi
, James D. Doecke
, Jurgen Fripp
, Olivier Salvado
, Peter J. Snyder
, Michael Weinborn
, Victor L. Villemagne
, Christopher C. Rowe
, Colin L. Masters
, Paul Maruff^*
, The AIBL Research Group

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

78 Downloads (Pure)

Abstract

Introduction: Superior cognitive performance in older adults may reflect underlying resistance to age-associated neurodegeneration. While elevated amyloid β (Aβ) deposition (Aβ+) has been associated with increased cortical atrophy, it remains unknown whether “SuperAgers” may be protected from Aβ-associated neurodegeneration. Methods: Neuropsychologically defined SuperAgers (n = 172) and cognitively normal for age (n = 172) older adults from the Australian Imaging, Biomarkers and Lifestyle study were case matched. Rates of cortical atrophy over 8 years were examined by SuperAger classification and Aβ status. Results: Of the case-matched SuperAgers and cognitively normal for age older adults, 40.7% and 40.1%, respectively, were Aβ+. Rates of age- and Aβ-associated atrophy did not differ between the groups on any measure. Aβ− individuals displayed the slowest rates of atrophy. Discussion: Maintenance of superior memory in late life does not reflect resistance to age- or Aβ-associated atrophy. However, those individuals who reached old age without cognitive impairment nor elevated Aβ deposition (i.e. Aβ−) displayed reduced rates of cortical atrophy.

Original language	English
Pages (from-to)	566-575
Number of pages	10
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	11
DOIs	https://doi.org/10.1016/j.dadm.2019.05.005
Publication status	Published - 1 Dec 2019
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Aging
Alzheimer's disease
Memory
Neurodegeneration
β-amyloid

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10.1016/j.dadm.2019.05.005

Publisher version (open access)Final published version, 775 KBLicence: CC BY-NC-ND

Cite this

Dang, C., Yassi, N., Harrington, K. D., Xia, Y., Lim, Y. Y., Ames, D., Laws, S. M., Hickey, M., Rainey-Smith, S., Sohrabi, H. R., Doecke, J. D., Fripp, J., Salvado, O., Snyder, P. J., Weinborn, M., Villemagne, V. L., Rowe, C. C., Masters, C. L., Maruff, P., & The AIBL Research Group (2019). Rates of age- and amyloid β-associated cortical atrophy in older adults with superior memory performance. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 11, 566-575. https://doi.org/10.1016/j.dadm.2019.05.005

@article{df091519ad864d7b81b316262d820238,

title = "Rates of age- and amyloid β-associated cortical atrophy in older adults with superior memory performance",

abstract = "Introduction: Superior cognitive performance in older adults may reflect underlying resistance to age-associated neurodegeneration. While elevated amyloid β (Aβ) deposition (Aβ+) has been associated with increased cortical atrophy, it remains unknown whether “SuperAgers” may be protected from Aβ-associated neurodegeneration. Methods: Neuropsychologically defined SuperAgers (n = 172) and cognitively normal for age (n = 172) older adults from the Australian Imaging, Biomarkers and Lifestyle study were case matched. Rates of cortical atrophy over 8 years were examined by SuperAger classification and Aβ status. Results: Of the case-matched SuperAgers and cognitively normal for age older adults, 40.7\% and 40.1\%, respectively, were Aβ+. Rates of age- and Aβ-associated atrophy did not differ between the groups on any measure. Aβ− individuals displayed the slowest rates of atrophy. Discussion: Maintenance of superior memory in late life does not reflect resistance to age- or Aβ-associated atrophy. However, those individuals who reached old age without cognitive impairment nor elevated Aβ deposition (i.e. Aβ−) displayed reduced rates of cortical atrophy.",

keywords = "Aging, Alzheimer's disease, Memory, Neurodegeneration, β-amyloid",

author = "Christa Dang and Nawaf Yassi and Harrington, \{Karra D.\} and Ying Xia and Lim, \{Yen Ying\} and David Ames and Laws, \{Simon M.\} and Martha Hickey and Stephanie Rainey-Smith and Sohrabi, \{Hamid R.\} and Doecke, \{James D.\} and Jurgen Fripp and Olivier Salvado and Snyder, \{Peter J.\} and Michael Weinborn and Villemagne, \{Victor L.\} and Rowe, \{Christopher C.\} and Masters, \{Colin L.\} and Paul Maruff and \{The AIBL Research Group\}",

note = "Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2019",

month = dec,

day = "1",

doi = "10.1016/j.dadm.2019.05.005",

language = "English",

volume = "11",

pages = "566--575",

journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",

issn = "2352-8729",

publisher = "John Wiley \& Sons",

}

Dang, C, Yassi, N, Harrington, KD, Xia, Y, Lim, YY, Ames, D, Laws, SM, Hickey, M, Rainey-Smith, S, Sohrabi, HR, Doecke, JD, Fripp, J, Salvado, O, Snyder, PJ, Weinborn, M, Villemagne, VL, Rowe, CC, Masters, CL, Maruff, P & The AIBL Research Group 2019, 'Rates of age- and amyloid β-associated cortical atrophy in older adults with superior memory performance', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 11, pp. 566-575. https://doi.org/10.1016/j.dadm.2019.05.005

TY - JOUR

T1 - Rates of age- and amyloid β-associated cortical atrophy in older adults with superior memory performance

AU - Dang, Christa

AU - Yassi, Nawaf

AU - Harrington, Karra D.

AU - Xia, Ying

AU - Lim, Yen Ying

AU - Ames, David

AU - Laws, Simon M.

AU - Hickey, Martha

AU - Rainey-Smith, Stephanie

AU - Sohrabi, Hamid R.

AU - Doecke, James D.

AU - Fripp, Jurgen

AU - Salvado, Olivier

AU - Snyder, Peter J.

AU - Weinborn, Michael

AU - Villemagne, Victor L.

AU - Rowe, Christopher C.

AU - Masters, Colin L.

AU - Maruff, Paul

AU - The AIBL Research Group

N1 - Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Introduction: Superior cognitive performance in older adults may reflect underlying resistance to age-associated neurodegeneration. While elevated amyloid β (Aβ) deposition (Aβ+) has been associated with increased cortical atrophy, it remains unknown whether “SuperAgers” may be protected from Aβ-associated neurodegeneration. Methods: Neuropsychologically defined SuperAgers (n = 172) and cognitively normal for age (n = 172) older adults from the Australian Imaging, Biomarkers and Lifestyle study were case matched. Rates of cortical atrophy over 8 years were examined by SuperAger classification and Aβ status. Results: Of the case-matched SuperAgers and cognitively normal for age older adults, 40.7% and 40.1%, respectively, were Aβ+. Rates of age- and Aβ-associated atrophy did not differ between the groups on any measure. Aβ− individuals displayed the slowest rates of atrophy. Discussion: Maintenance of superior memory in late life does not reflect resistance to age- or Aβ-associated atrophy. However, those individuals who reached old age without cognitive impairment nor elevated Aβ deposition (i.e. Aβ−) displayed reduced rates of cortical atrophy.

AB - Introduction: Superior cognitive performance in older adults may reflect underlying resistance to age-associated neurodegeneration. While elevated amyloid β (Aβ) deposition (Aβ+) has been associated with increased cortical atrophy, it remains unknown whether “SuperAgers” may be protected from Aβ-associated neurodegeneration. Methods: Neuropsychologically defined SuperAgers (n = 172) and cognitively normal for age (n = 172) older adults from the Australian Imaging, Biomarkers and Lifestyle study were case matched. Rates of cortical atrophy over 8 years were examined by SuperAger classification and Aβ status. Results: Of the case-matched SuperAgers and cognitively normal for age older adults, 40.7% and 40.1%, respectively, were Aβ+. Rates of age- and Aβ-associated atrophy did not differ between the groups on any measure. Aβ− individuals displayed the slowest rates of atrophy. Discussion: Maintenance of superior memory in late life does not reflect resistance to age- or Aβ-associated atrophy. However, those individuals who reached old age without cognitive impairment nor elevated Aβ deposition (i.e. Aβ−) displayed reduced rates of cortical atrophy.

KW - Aging

KW - Alzheimer's disease

KW - Memory

KW - Neurodegeneration

KW - β-amyloid

UR - https://www.scopus.com/pages/publications/85070370939

U2 - 10.1016/j.dadm.2019.05.005

DO - 10.1016/j.dadm.2019.05.005

M3 - Article

C2 - 31909172

AN - SCOPUS:85070370939

SN - 2352-8729

VL - 11

SP - 566

EP - 575

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

ER -

Rates of age- and amyloid β-associated cortical atrophy in older adults with superior memory performance

Abstract

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Keywords

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