Real time intraoperative confocal laser microscopy-guided surgery

Nam Q. Nguyen, Andrew V. Biankin, Rupert W L Leong, David K. Chang, Peter H. Cosman, Peter Delaney, James G. Kench, Neil D. Merrett

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

OBJECTIVE:: To assess the potential utility of in vivo histologic surface and subsurface imaging in real-time using the Optiscan confocal laser microscope to detect diseased tissue at the time of surgery. SUMMARY BACKGROUND DATA:: The goal of surgical treatment of diseases such as cancer is complete microscopic resection of diseased tissue; however, current methods for the assessment of extent of disease at the time of surgery are inadequate. METHODS:: We assessed the potential of the Optiscan confocal laser microscope, a new device developed for real-time in vivo histologic surface and subsurface imaging during surgery. RESULTS:: Intravenous Fluorescein Sodium contrast enabled visualization of cellular and architectural morphology of intra-abdominal organs with magnification equivalent to light microscopy and enabled differentiation between normal organs and disease. CONCLUSIONS:: Real time intraoperative confocal microscopy has significant potential application in detecting disease, and influencing decision-making at the time of surgery.

Original languageEnglish
Pages (from-to)735-737
Number of pages3
JournalAnnals of Surgery
Volume249
Issue number5
DOIs
Publication statusPublished - May 2009
Externally publishedYes

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