Real-time MRI-guided interstitial laser therapy for inoperable renal lesions

A novel therapeutic approach?

J. L. Probert*, R. A. Persad, P. Goddard, M. Hetzel, D. A. Gillattt

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Introduction: In patients with renal lesions which may be amenable to resection but in whom surgery is contraindicated, interstitial laser therapy may provide a novel therapeutic approach in the future. The advent of an open-coil MRI scanner in our unit allows interventional procedures to be performed under the guidance of real-time images. This technique was used to examine the effect of interstitial laser therapy on cadaveric liver and kidney tissue. Materials and methods: Cadaveric livers and kidneys were procured; the organs were imaged at 0.5 Tesla using an opencoil MRI unit. Using real-time images, an interstitial laser was introduced and used to achieve a suitable volume of coagulation necrosis, which was recorded on MRI. These images were then correlated with a macroscopic examination of the coagulated area in the open specimen. Results: Good necrosis is achieved in the cadaveric specimens using the laser. Correlation with open specimens showed that real-time MRI is accurate in locating a particular area of an organ, and also in determining the volume of tissue necrosed. Conclusions: Interstitial laser coagulation is a novel therapeutic approach for treating renal lesions which is still in its infancy. However, our early results have been promising and this technique is currently undergoing further research.

Original languageEnglish
Pages (from-to)59
Number of pages1
JournalBritish Journal of Urology
Volume81
Issue numberSUPPL. 4
Publication statusPublished - 1998
Externally publishedYes

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