Alzheimer's disease(AD) is one of the most important progressive neurological diseases, which is characterized by the formation, misfolding, and aggregation of β-amyloid protein(Aβ). Based on the special blood brain barrier(BBB) system and protein structure of Aβ, a variety of multifunctional Aβ fluorescent probes with high sensitivity, facile operation, and low toxicity, were developed for the detection and treatment of AD. This review respectively focused on the imaging detection and therapy of Aβ, and systematically reviewed the chemical regulation strategy for brain-target design, wavelength regulation, and integration of diagnosis with treatment. In the end, the perspective for the multifunctional fluorescent Aβ probes was also discussed.
|Translated title of the contribution||Recent advances in fabricating the multifunctional Aβ small organic molecule probes for theranostic application|
|Number of pages||11|
|Journal||Gaodeng Xuexiao Huaxue Xuebao/Chemical Journal of Chinese Universities|
|Publication status||Published - 10 Nov 2021|
- Alzheimer's disease
- β-Amyloid protein