多功能Aβ有机小分子探针的构建及诊疗应用进展

Translated title of the contribution: Recent advances in fabricating the multifunctional Aβ small organic molecule probes for theranostic application

Xiaoyu Chen, Yisheng Liu, Mu He, Ping Shangguan, Lulu Han, Jiefei Wang*, Bingyang Shi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Alzheimer's disease(AD) is one of the most important progressive neurological diseases, which is characterized by the formation, misfolding, and aggregation of β-amyloid protein(Aβ). Based on the special blood brain barrier(BBB) system and protein structure of Aβ, a variety of multifunctional Aβ fluorescent probes with high sensitivity, facile operation, and low toxicity, were developed for the detection and treatment of AD. This review respectively focused on the imaging detection and therapy of Aβ, and systematically reviewed the chemical regulation strategy for brain-target design, wavelength regulation, and integration of diagnosis with treatment. In the end, the perspective for the multifunctional fluorescent Aβ probes was also discussed.

Translated title of the contributionRecent advances in fabricating the multifunctional Aβ small organic molecule probes for theranostic application
Original languageCantonese
Pages (from-to)3310-3320
Number of pages11
JournalGaodeng Xuexiao Huaxue Xuebao/Chemical Journal of Chinese Universities
Volume42
Issue number11
DOIs
Publication statusPublished - 10 Nov 2021
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Fluorescence
  • Theranostic
  • β-Amyloid protein

Fingerprint

Dive into the research topics of 'Recent advances in fabricating the multifunctional Aβ small organic molecule probes for theranostic application'. Together they form a unique fingerprint.

Cite this