Recent advances in mapping the sub-cellular distribution of metal-based anticancer drugs

Louise E. Wedlock, Susan J. Berners-Price*

*Corresponding author for this work

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

There are increasing reports of novel metal-based chemotherapeutics that have either improved cancer cell selectivity, or alternative mechanisms of action, to existing anticancer drugs, and techniques are required for determining their sub-cellular molecular targets. Imaging methods offer many distinct advantages over destructive fractionation techniques, including the preservation of useful morphological information; however, mapping the intracellular distribution of metal ions inside tumour cells still remains challenging. Recent advances in three modes of imaging are discussed in this review, with a particular focus on the application to metal-based cancer chemotherapy fluorescence microscopy, electron microscopy (including energy-filtered transmission electron microscopy (EFTEM)), and a new technique, Nano-scale secondary ion mass spectrometry (NanoSIMS).

Original languageEnglish
Pages (from-to)692-704
Number of pages13
JournalAustralian Journal of Chemistry
Volume64
Issue number6
DOIs
Publication statusPublished - 2011
Externally publishedYes

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