Recent advances in synthetic biology for engineering isoprenoid production in yeast

Claudia E. Vickers, Thomas C. Williams, Bingyin Peng, Joel Cherry

    Research output: Contribution to journalReview articlepeer-review

    117 Citations (Scopus)


    Isoprenoids (terpenes/terpenoids) have many useful industrial applications, but are often not produced at industrially viable level in their natural sources. Synthetic biology approaches have been used extensively to reconstruct metabolic pathways in tractable microbial hosts such as yeast and re-engineer pathways and networks to increase yields. Here we review recent advances in this field, focusing on central carbon metabolism engineering to increase precursor supply, re-directing carbon flux for production of C10, C15, or C20 isoprenoids, and chemical decoration of high value diterpenoids (C20). We also overview other novel synthetic biology strategies that have potential utility in yeast isoprenoid pathway engineering. Finally, we address the question of what is required in the future to move the field forwards.

    Original languageEnglish
    Pages (from-to)47-56
    Number of pages10
    JournalCurrent Opinion in Chemical Biology
    Publication statusPublished - Oct 2017


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