Recombinant glycoprotein production in the slime mould Dictyostelium discoideum

Keith L. Williams*, Kerry R. Emslie, Martin B. Slade

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Dictyostelium discoideum is a well known amoeboid organism, with unicellular and multicellular life-cycle stages, that is used for studying cell and developmental biology. With advances in gene-disruption technology and transformation of this organism, many homologous proteins have been expressed either to complement defective proteins or to study basic cell biology. Now, D. discoideum is being used to express heterologous proteins that are difficult to study in other systems, and its unique cell biology is being exploited to facilitate a wide range of protein modifications. In the past year, substantial progress has been made in expressing correctly folded forms of malarial circumsporozoite antigen and rotavirus surface glycoprotein VP7. Exciting developments have also been made in expressing human muscarinic receptors.

Original languageEnglish
Pages (from-to)538-542
Number of pages5
JournalCurrent Opinion in Biotechnology
Volume6
Issue number5
DOIs
Publication statusPublished - 1995

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