TY - JOUR
T1 - Recommendations for the conduct of economic evaluations in osteoporosis
T2 - outcomes of an experts’ consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the US branch of the International Osteoporosis Foundation
AU - Hiligsmann, M.
AU - Reginster, J. Y.
AU - Tosteson, A. N. A.
AU - Bukata, S. V.
AU - Saag, K. G.
AU - Gold, D. T.
AU - Halbout, P.
AU - Jiwa, F.
AU - Lewiecki, E. M.
AU - Pinto, D.
AU - Adachi, J. D.
AU - Al-Daghri, N.
AU - Bruyère, O.
AU - Chandran, M.
AU - Cooper, C.
AU - Harvey, N. C.
AU - Einhorn, T. A.
AU - Kanis, J. A.
AU - Kendler, D. L.
AU - Messina, O. D.
AU - Rizzoli, R.
AU - Si, L.
AU - Silverman, S.
N1 - Copyrignt The Author(s) 2018. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
PY - 2019/1/18
Y1 - 2019/1/18
N2 - Summary: Economic evaluations are increasingly used to assess the value of health interventions, but variable quality and heterogeneity limit the use of these evaluations by decision-makers. These recommendations provide guidance for the design, conduct, and reporting of economic evaluations in osteoporosis to improve their transparency, comparability, and methodologic standards.Introduction: This paper aims to provide recommendations for the conduct of economic evaluations in osteoporosis in order to improve their transparency, comparability, and methodologic standards.Methods: A working group was convened by the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis to make recommendations for the design, conduct, and reporting of economic evaluations in osteoporosis, to define an osteoporosis-specific reference case to serve a minimum standard for all economic analyses in osteoporosis, to discuss methodologic challenges and initiate a call for research. A literature review, a face-to-face meeting in New York City (including 11 experts), and a review/approval by a larger group of experts worldwide (including 23 experts in total) were conducted.Results: Recommendations on the type of economic evaluation, methods for economic evaluation, modeling aspects, base-case analysis and population, excess mortality, fracture costs and disutility, treatment characteristics, and model validation were provided. Recommendations for reporting economic evaluations in osteoporosis were also made and an osteoporosis-specific checklist was designed that includes items to report when performing an economic evaluation in osteoporosis. Further, 12 minimum criteria for economic evaluations in osteoporosis were identified and 12 methodologic challenges and need for further research were discussed.Conclusion: While the working group acknowledges challenges and the need for further research, these recommendations are intended to supplement general and national guidelines for economic evaluations, improve transparency, quality, and comparability of economic evaluations in osteoporosis, and maintain methodologic standards to increase their use by decision-makers.
AB - Summary: Economic evaluations are increasingly used to assess the value of health interventions, but variable quality and heterogeneity limit the use of these evaluations by decision-makers. These recommendations provide guidance for the design, conduct, and reporting of economic evaluations in osteoporosis to improve their transparency, comparability, and methodologic standards.Introduction: This paper aims to provide recommendations for the conduct of economic evaluations in osteoporosis in order to improve their transparency, comparability, and methodologic standards.Methods: A working group was convened by the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis to make recommendations for the design, conduct, and reporting of economic evaluations in osteoporosis, to define an osteoporosis-specific reference case to serve a minimum standard for all economic analyses in osteoporosis, to discuss methodologic challenges and initiate a call for research. A literature review, a face-to-face meeting in New York City (including 11 experts), and a review/approval by a larger group of experts worldwide (including 23 experts in total) were conducted.Results: Recommendations on the type of economic evaluation, methods for economic evaluation, modeling aspects, base-case analysis and population, excess mortality, fracture costs and disutility, treatment characteristics, and model validation were provided. Recommendations for reporting economic evaluations in osteoporosis were also made and an osteoporosis-specific checklist was designed that includes items to report when performing an economic evaluation in osteoporosis. Further, 12 minimum criteria for economic evaluations in osteoporosis were identified and 12 methodologic challenges and need for further research were discussed.Conclusion: While the working group acknowledges challenges and the need for further research, these recommendations are intended to supplement general and national guidelines for economic evaluations, improve transparency, quality, and comparability of economic evaluations in osteoporosis, and maintain methodologic standards to increase their use by decision-makers.
KW - Cost-effectiveness
KW - Economic evaluation
KW - Osteoporosis
KW - Recommendations
KW - Reference case
UR - http://www.scopus.com/inward/record.url?scp=85056094473&partnerID=8YFLogxK
U2 - 10.1007/s00198-018-4744-x
DO - 10.1007/s00198-018-4744-x
M3 - Article
C2 - 30382319
AN - SCOPUS:85056094473
SN - 0937-941X
VL - 30
SP - 45
EP - 57
JO - Osteoporosis International
JF - Osteoporosis International
IS - 1
ER -