Recovery from macular phototoxicity after corneal triple procedure

Nathaniel E. Knox Cartwright; Derek M. Tole; Richard J. Haynes; John J. Males; Andrew D. Dick; Eric J. Mayer

doi:10.1097/01.ico.0000240102.51852.5a

Recovery from macular phototoxicity after corneal triple procedure

Nathaniel E. Knox Cartwright, Derek M. Tole, Richard J. Haynes, John J. Males, Andrew D. Dick, Eric J. Mayer^*

^*Corresponding author for this work

Faculty of Medicine, Health and Human Sciences

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

PURPOSE: Visual recovery from macular phototoxicity in 2 cases after prolonged exposure to operating microscope light from uncomplicated corneal triple-procedure surgery. Recovery is discussed in the context of repair and regeneration. METHODS: Retrospective case reports. RESULTS: Immediately postoperatively, both patients reported positive scotomata and were found to have macular retinal pigment epithelial depigmentation. In 1 case, the fovea was involved. By 6 to 12 months, the scotomata had disappeared despite large areas of retinal pigment epithelial hyperpigmentation remaining. CONCLUSION: Recovery from macular phototoxicity occurs, although the mechanism remains unclear. Positive scotomata in these cases resolved over several months. The time scale of recovery was consistent with the time required for cellular replacement and possible differentiation from neural progenitor cells.

Original language	English
Pages (from-to)	102-104
Number of pages	3
Journal	Cornea
Volume	26
Issue number	1
DOIs	https://doi.org/10.1097/01.ico.0000240102.51852.5a
Publication status	Published - Jan 2007

Keywords

Cataract surgery
Corneal transplant surgery
Progenitor cells
Recovery
Retinal phototoxicity

Access to Document

10.1097/01.ico.0000240102.51852.5a

Cite this

@article{a1d9a031f61d4d55a8da8b4897815191,

title = "Recovery from macular phototoxicity after corneal triple procedure",

abstract = "PURPOSE: Visual recovery from macular phototoxicity in 2 cases after prolonged exposure to operating microscope light from uncomplicated corneal triple-procedure surgery. Recovery is discussed in the context of repair and regeneration. METHODS: Retrospective case reports. RESULTS: Immediately postoperatively, both patients reported positive scotomata and were found to have macular retinal pigment epithelial depigmentation. In 1 case, the fovea was involved. By 6 to 12 months, the scotomata had disappeared despite large areas of retinal pigment epithelial hyperpigmentation remaining. CONCLUSION: Recovery from macular phototoxicity occurs, although the mechanism remains unclear. Positive scotomata in these cases resolved over several months. The time scale of recovery was consistent with the time required for cellular replacement and possible differentiation from neural progenitor cells.",

keywords = "Cataract surgery, Corneal transplant surgery, Progenitor cells, Recovery, Retinal phototoxicity",

author = "{Knox Cartwright}, {Nathaniel E.} and Tole, {Derek M.} and Haynes, {Richard J.} and Males, {John J.} and Dick, {Andrew D.} and Mayer, {Eric J.}",

year = "2007",

month = jan,

doi = "10.1097/01.ico.0000240102.51852.5a",

language = "English",

volume = "26",

pages = "102--104",

journal = "Cornea",

issn = "0277-3740",

publisher = "Lippincott Williams and Wilkins",

number = "1",

}

TY - JOUR

T1 - Recovery from macular phototoxicity after corneal triple procedure

AU - Knox Cartwright, Nathaniel E.

AU - Tole, Derek M.

AU - Haynes, Richard J.

AU - Males, John J.

AU - Dick, Andrew D.

AU - Mayer, Eric J.

PY - 2007/1

Y1 - 2007/1

N2 - PURPOSE: Visual recovery from macular phototoxicity in 2 cases after prolonged exposure to operating microscope light from uncomplicated corneal triple-procedure surgery. Recovery is discussed in the context of repair and regeneration. METHODS: Retrospective case reports. RESULTS: Immediately postoperatively, both patients reported positive scotomata and were found to have macular retinal pigment epithelial depigmentation. In 1 case, the fovea was involved. By 6 to 12 months, the scotomata had disappeared despite large areas of retinal pigment epithelial hyperpigmentation remaining. CONCLUSION: Recovery from macular phototoxicity occurs, although the mechanism remains unclear. Positive scotomata in these cases resolved over several months. The time scale of recovery was consistent with the time required for cellular replacement and possible differentiation from neural progenitor cells.

AB - PURPOSE: Visual recovery from macular phototoxicity in 2 cases after prolonged exposure to operating microscope light from uncomplicated corneal triple-procedure surgery. Recovery is discussed in the context of repair and regeneration. METHODS: Retrospective case reports. RESULTS: Immediately postoperatively, both patients reported positive scotomata and were found to have macular retinal pigment epithelial depigmentation. In 1 case, the fovea was involved. By 6 to 12 months, the scotomata had disappeared despite large areas of retinal pigment epithelial hyperpigmentation remaining. CONCLUSION: Recovery from macular phototoxicity occurs, although the mechanism remains unclear. Positive scotomata in these cases resolved over several months. The time scale of recovery was consistent with the time required for cellular replacement and possible differentiation from neural progenitor cells.

KW - Cataract surgery

KW - Corneal transplant surgery

KW - Progenitor cells

KW - Recovery

KW - Retinal phototoxicity

UR - http://www.scopus.com/inward/record.url?scp=33846015031&partnerID=8YFLogxK

U2 - 10.1097/01.ico.0000240102.51852.5a

DO - 10.1097/01.ico.0000240102.51852.5a

M3 - Article

C2 - 17198023

AN - SCOPUS:33846015031

VL - 26

SP - 102

EP - 104

JO - Cornea

JF - Cornea

SN - 0277-3740

IS - 1

ER -

Recovery from macular phototoxicity after corneal triple procedure

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this