Recruitment of myeloid cells to the tumor microenvironment supports liver metastasis

Su Yin Lim, Alex N. Gordon-Weeks, Lei Zhao, Thomas T. Tapmeier, Jae Hong Im, Yunhong Cao, John Beech, Danny Allen, Sean Smart, Ruth J. Muschel*

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Tumor-infiltrating immune cells play important roles in metastasis. We have recently revealed the recruitment of a specific myeloid cell subset (CD11b/Gr1mid) to hepatic metastases. Such a recruitment relies on CCL2/CCR2 signaling and acts to sustain metastatic growth. A similar cell subset was identified in patients bearing hepatic metastases of colorectal cancer, highlighting the potential therapeutic relevance of our findings.

Original languageEnglish
Article numbere23187
Pages (from-to)1-2
Number of pages2
JournalOncoImmunology
Volume2
Issue number3
DOIs
Publication statusPublished - Mar 2013
Externally publishedYes

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