Recruitment of myeloid cells to the tumor microenvironment supports liver metastasis

Su Yin Lim; Alex N. Gordon-Weeks; Lei Zhao; Thomas T. Tapmeier; Jae Hong Im; Yunhong Cao; John Beech; Danny Allen; Sean Smart; Ruth J. Muschel

doi:10.4161/onci.23187

Recruitment of myeloid cells to the tumor microenvironment supports liver metastasis

Su Yin Lim, Alex N. Gordon-Weeks, Lei Zhao, Thomas T. Tapmeier, Jae Hong Im, Yunhong Cao, John Beech, Danny Allen, Sean Smart, Ruth J. Muschel^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Tumor-infiltrating immune cells play important roles in metastasis. We have recently revealed the recruitment of a specific myeloid cell subset (CD11b/Gr1^mid) to hepatic metastases. Such a recruitment relies on CCL2/CCR2 signaling and acts to sustain metastatic growth. A similar cell subset was identified in patients bearing hepatic metastases of colorectal cancer, highlighting the potential therapeutic relevance of our findings.

Original language	English
Article number	e23187
Pages (from-to)	1-2
Number of pages	2
Journal	OncoImmunology
Volume	2
Issue number	3
DOIs	https://doi.org/10.4161/onci.23187
Publication status	Published - Mar 2013
Externally published	Yes

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title = "Recruitment of myeloid cells to the tumor microenvironment supports liver metastasis",

abstract = "Tumor-infiltrating immune cells play important roles in metastasis. We have recently revealed the recruitment of a specific myeloid cell subset (CD11b/Gr1mid) to hepatic metastases. Such a recruitment relies on CCL2/CCR2 signaling and acts to sustain metastatic growth. A similar cell subset was identified in patients bearing hepatic metastases of colorectal cancer, highlighting the potential therapeutic relevance of our findings.",

author = "Lim, \{Su Yin\} and Gordon-Weeks, \{Alex N.\} and Lei Zhao and Tapmeier, \{Thomas T.\} and Im, \{Jae Hong\} and Yunhong Cao and John Beech and Danny Allen and Sean Smart and Muschel, \{Ruth J.\}",

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AU - Lim, Su Yin

AU - Gordon-Weeks, Alex N.

AU - Zhao, Lei

AU - Tapmeier, Thomas T.

AU - Im, Jae Hong

AU - Cao, Yunhong

AU - Beech, John

AU - Allen, Danny

AU - Smart, Sean

AU - Muschel, Ruth J.

PY - 2013/3

Y1 - 2013/3

N2 - Tumor-infiltrating immune cells play important roles in metastasis. We have recently revealed the recruitment of a specific myeloid cell subset (CD11b/Gr1mid) to hepatic metastases. Such a recruitment relies on CCL2/CCR2 signaling and acts to sustain metastatic growth. A similar cell subset was identified in patients bearing hepatic metastases of colorectal cancer, highlighting the potential therapeutic relevance of our findings.

AB - Tumor-infiltrating immune cells play important roles in metastasis. We have recently revealed the recruitment of a specific myeloid cell subset (CD11b/Gr1mid) to hepatic metastases. Such a recruitment relies on CCL2/CCR2 signaling and acts to sustain metastatic growth. A similar cell subset was identified in patients bearing hepatic metastases of colorectal cancer, highlighting the potential therapeutic relevance of our findings.

UR - https://www.scopus.com/pages/publications/84886944431

U2 - 10.4161/onci.23187

DO - 10.4161/onci.23187

M3 - Article

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AN - SCOPUS:84886944431

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JO - OncoImmunology

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IS - 3

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ER -

Recruitment of myeloid cells to the tumor microenvironment supports liver metastasis

Abstract

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