Recurrence of progressive multifocal leukoencephalopathy despite immune recovery in two HIV seropositive individuals

Kate M. Crossley; Shruti Agnihotri; Joga Chaganti; Michael L. Rodriguez; Leon Patrick McNally; Nagagopal Venna; Sarah E. Turbett; Matthew Gutman; Adrienne Morey; Igor J. Koralnik; Bruce J. Brew

doi:10.1007/s13365-015-0419-y

Recurrence of progressive multifocal leukoencephalopathy despite immune recovery in two HIV seropositive individuals

Kate M. Crossley^*, Shruti Agnihotri, Joga Chaganti, Michael L. Rodriguez, Leon Patrick McNally, Nagagopal Venna, Sarah E. Turbett, Matthew Gutman, Adrienne Morey, Igor J. Koralnik, Bruce J. Brew

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

We present two cases of recurrent progressive multifocal leukoencephalopathy (PML) in patients with long standing virally suppressed human immunodeficiency virus (HIV) and normal CD4+ T cell count who were taking stable regimens of highly active antiretroviral therapy (HAART). This has significant implications for other patients with a past history of PML, not just those with HIV but also those on medications such as natalizumab or fumarates.

Original language	English
Pages (from-to)	541-545
Number of pages	5
Journal	Journal of NeuroVirology
Volume	22
Issue number	4
DOIs	https://doi.org/10.1007/s13365-015-0419-y
Publication status	Published - 1 Aug 2016
Externally published	Yes

Bibliographical note

Copyright the Author(s). Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Neuroimmunology
Neurovirology
Progressive multifocal leukoencephalopathy

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10.1007/s13365-015-0419-y

Publisher version (open access)Final published version, 3.28 MBLicence: CC BY

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Crossley, K. M., Agnihotri, S., Chaganti, J., Rodriguez, M. L., McNally, L. P., Venna, N., Turbett, S. E., Gutman, M., Morey, A., Koralnik, I. J., & Brew, B. J. (2016). Recurrence of progressive multifocal leukoencephalopathy despite immune recovery in two HIV seropositive individuals. Journal of NeuroVirology, 22(4), 541-545. https://doi.org/10.1007/s13365-015-0419-y

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abstract = "We present two cases of recurrent progressive multifocal leukoencephalopathy (PML) in patients with long standing virally suppressed human immunodeficiency virus (HIV) and normal CD4+ T cell count who were taking stable regimens of highly active antiretroviral therapy (HAART). This has significant implications for other patients with a past history of PML, not just those with HIV but also those on medications such as natalizumab or fumarates.",

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note = "Copyright the Author(s). Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

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doi = "10.1007/s13365-015-0419-y",

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T1 - Recurrence of progressive multifocal leukoencephalopathy despite immune recovery in two HIV seropositive individuals

AU - Crossley, Kate M.

AU - Agnihotri, Shruti

AU - Chaganti, Joga

AU - Rodriguez, Michael L.

AU - McNally, Leon Patrick

AU - Venna, Nagagopal

AU - Turbett, Sarah E.

AU - Gutman, Matthew

AU - Morey, Adrienne

AU - Koralnik, Igor J.

AU - Brew, Bruce J.

N1 - Copyright the Author(s). Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - We present two cases of recurrent progressive multifocal leukoencephalopathy (PML) in patients with long standing virally suppressed human immunodeficiency virus (HIV) and normal CD4+ T cell count who were taking stable regimens of highly active antiretroviral therapy (HAART). This has significant implications for other patients with a past history of PML, not just those with HIV but also those on medications such as natalizumab or fumarates.

AB - We present two cases of recurrent progressive multifocal leukoencephalopathy (PML) in patients with long standing virally suppressed human immunodeficiency virus (HIV) and normal CD4+ T cell count who were taking stable regimens of highly active antiretroviral therapy (HAART). This has significant implications for other patients with a past history of PML, not just those with HIV but also those on medications such as natalizumab or fumarates.

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KW - Neurovirology

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IS - 4

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Recurrence of progressive multifocal leukoencephalopathy despite immune recovery in two HIV seropositive individuals

Abstract

Bibliographical note

Keywords

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